Publications by authors named "Sapin A"

Symptomatic effects of mental disorders in parents could bias their reporting on their child's mental health. This study aimed to investigate the measurement invariance of the French version of the parental Strengths and Difficulties Questionnaire (SDQ) across parental mental health in a sample (N = 20,765) of parents of children aged 3 to 17 years in France. Confirmatory factor analysis (CFA) and Exploratory Structural Equation Modelling (ESEM) were used to evaluate the fit of three known alternative SDQ factor structures (five, three, or second-order factor structures).

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Introduction: Vaccination is one of the most effective ways to stop the COVID-19 pandemic and prevent severe disease. This study aims to ascertain the determinants of COVID-19 vaccination acceptance in the French population before the vaccine was introduced (France's second lockdown) and during the roll-out of the vaccination campaign (France's third lockdown). We focus on the following as determinants of willingness to be vaccinated: risk perception, affects related to the risk, and trust in political and health institutions.

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  • Medical devices often use plasticized polyvinylchloride (PVC), but plasticizers can leach into solutions, posing a toxic risk to patients.
  • The study aims to fluorinate PVC medical devices to create a barrier that limits plasticizer migration, and the process successfully formed C-F bonds without changing the devices' mechanical or optical properties.
  • Testing showed that plasticizer migration from the fluorinated devices was significantly reduced and remained below detectable levels after 24 hours, with no cytotoxic effects observed on cells tested.
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Background: Storage of frozen plasma samples for hemostasis testing is a key step to obtain reliable results. Variables that can affect the quality of plasma during storage include the cryotube type and volume and the tube filling level that conditions the residual air volume. To date, there are only few data on which to base recommendations.

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Background: The ISTH-SSC guidelines for lupus anticoagulant (LA) testing recommend using in-house determined cut-off values, pooled normal plasma (PNP) for ratio normalization, and a ratio for the mixing test interpretation. They strongly support the mixing step role in the diagnostic process.

Objectives: To investigate and compare the LA testing results and interpretations obtained following the ISTH-SSC guidelines or the available alternatives.

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The COVID-19 pandemic remains hugely challenging, but its impact on emotional experience, especially over time, has often been neglected. The French Government imposed three COVID lockdowns with varying degrees of strictness that induced different types of emotional discomfort and emotion regulation. The present longitudinal study explored affect and emotion regulation strategies in each of these lockdowns, comparing samples assessed before and during the pandemic.

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Objective: COVID 19 is often associated with hypercoagulability and thromboembolic (TE) events. The aim of this study was to assess the characteristics of hypercoagulability and its relationship with new-onset TE events and the composite outcome of need for intubation and/or death in intensive care unit (ICU) patients admitted for COVID.

Design: Prospective observational study.

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  • The study investigates the stability of coagulation parameters in thawed plasma samples to improve laboratory handling and testing procedures.
  • It evaluates various coagulation measures after a freeze/thaw cycle in both normal and anticoagulated patients using specific assays.
  • Results indicate that certain parameters maintain stability for a limited time after thawing, emphasizing the need for careful management of sample timing during testing.
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Background: Enhanced Recovery After Surgery (ERAS) is a paradigm shift in perioperative care and incorporates patient-centered, evidence-based, and multidisciplinary team-developed pathways for a surgical specialty. ERAS pathways aim to reduce the patient's surgical stress response, optimize their physiologic function, facilitate recovery, and reduce the length of stay. The bariatric program at our institution was previously managed by many surgeons with anecdotal preferences, resulting in increased costs, lengths of stay, and opioid prescribing.

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  • Studying coagulation in newborns and children is challenging because they have low levels of factors that promote clotting and inhibitors.
  • The research compares thrombin generation in a pediatric group of 586 children to 166 adults using a specific assay method to assess coagulation.
  • Results show that while children's coagulation potential is lower without thrombomodulin, it normalizes with the presence of thrombomodulin, indicating that their coagulation balance is effectively maintained.
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Sodium-reduction initiatives have been a cornerstone of preventing hypertension and broader atherosclerotic cardiovascular disease (ASCVD) since the early 1970s. For nearly 50 years, public health and clinical guidelines have concentrated on consumer education, behavioral change, and, to a lesser extent, food policy to help reduce sodium intake among Americans. While these efforts undoubtedly helped improve awareness, average sodium consumption remains at approximately 4200 mg/day in men and 3000 mg/day in women, well above the United States Dietary Guidelines of 2300 mg/day.

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  • The study looked at how cooking classes can help families eat healthier, especially following the Mediterranean diet.
  • Families who took cooking classes were almost three times more likely to stick to this healthy diet compared to those who just received advice without cooking.
  • Participating in these cooking classes also helped families save money on food by encouraging them to make meals at home instead of buying prepared ones.
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Introduction: Chronic neutrophilic leukemia (CNL) is a rare myeloproliferative syndrome characterized by a significant increase in mature neutrophils. One of the most serious complications is the occurrence of bleeding events, which may sometimes lead to death.

Case Report: A 75-year-old patient presented with CNL, complicated by a severe bleeding phenotype.

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Adherence to Mediterranean dietary patterns reduces the incidence of cardiovascular disease and other major chronic diseases. We aimed to assess the association between participation in kitchen-based nutrition education and Mediterranean diet intake and lifestyle medicine counseling competencies among medical trainees. The Cooking for Health Optimization with Patients (CHOP) curriculum is a hands-on cooking-based nutrition education program implemented at 32 medical programs (4125 medical trainees) across the United States.

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Hb Dompierre [β29(B11)Gly→Arg, : c.88G>C] is a rare β-globin gene variant that was previously described in the heterozygous state in a 24-year-old female patient. It is defined in the HbVar database as being clinically and biologically asymptomatic.

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. Reducing the under-30-day readmission for heart failure (HF) patients is a modifiable quality-of-care measure, yet the role of diet in HF readmissions and cost-effective HF care remain ill-defined. .

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Methicillin resistance in (MRSA) is classically conferred by the acquisition of the A gene encoding an additional penicillin binding protein with low affinity for beta-lactams. A A variant, named C, was described in 2011. MRSA isolates harboring C of both animal and human origin have since been collected in different European countries.

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Despite numerous studies suggesting that amphibians are highly sensitive to endocrine disruptors (EDs), both their role in the decline of populations and the underlying mechanisms remain unclear. This study showed that frogs exposed throughout their life cycle to ED concentrations low enough to be considered safe for drinking water, developed a prediabetes phenotype and, more commonly, a metabolic syndrome. Female exposed from tadpole stage to benzo()pyrene or triclosan at concentrations of 50 ng⋅L displayed glucose intolerance syndrome, liver steatosis, liver mitochondrial dysfunction, liver transcriptomic signature, and pancreatic insulin hypersecretion, all typical of a prediabetes state.

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  • Botulism, caused by a neurotoxin from Clostridium botulinum, is mostly linked to ingestion or drug use, while wound botulism is rare with only 1-2 cases yearly in the U.S.
  • A 27-year-old man developed muscle weakness and other symptoms 10 days after a gunshot wound, leading to a diagnosis of wound botulism and the necessity of mechanical ventilation.
  • Emergency physicians should be aware that wound botulism is becoming more common in adults and needs to be considered for any patient showing neuromuscular symptoms with a recent injury, regardless of wound appearance.
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The aims of this study were to determine depuration rates for a range of per- and polyfluoroalkyl substances (PFASs) using Chironomus riparius, and to test a concentration-dependency hypothesis for the long-chain perfluorotridecanoic acid (PFTrDA) for this species. Midge larvae were exposed to field sediments collected downstream of a fluorotelomer plant, and to the same sediment spiked with PFTrDA. Elimination kinetics results indicated complete elimination of all PFASs by chironomids after 42h.

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Background: The purpose of the work was to assess the contribution to diagnosis and/or treatment (CDT) of bone marrow aspiration (BMA) in the critically ill patient.

Methods: The retrospective study included 193 patients. On the basis of BMA findings, contribution to diagnosis was defined by one of four previously unestablished diagnoses (maturation arrest of granulocyte precursors, hemophagocytic lymphohistiocytosis, hematological malignancy, marrow infiltration with cancer cells) and to treatment as the initiation or withdrawal of a specific treatment including the decision to forgo life-sustaining treatment (DFLST).

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The mechanisms that drive the transition from commensality to invasiveness in Staphylococcus aureus are poorly understood. We recently reported that >50% of S. aureus isolates from uninfected diabetic foot ulcers in French patients harbor a prophage, ROSA-like, that is absent from invasive isolates from diabetic foot infections, including osteomyelitis.

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Gammarids were exposed to sediments from a deposition site located on the Rhône River (France) downstream of a fluoropolymer manufacturing plant. Gammarids accumulated to various extents four long-chain perfluoroalkyl carboxylic acids (PFCAs) from C9 to C13, one sulfonate, perfluorooctane sulfonate (PFOS) and three of its precursors (the perflurooctane sulfonamide (FOSA), the N-methyl perfluorooctane sulfonamidoacetic acid (MeFOSAA), the N-ethyl perfluorooctane sulfonamidoacetic acid (EtFOSAA) and the 6:2 fluorotelomer sulfonic acid (6:2 FTSA). Whatever the compound, the steady state was not achieved after a 3-week exposure; elimination was almost complete after a 3-week depuration period for perfluorononanoic acid (PFNA), PFOS, the three precursors and the 6:2FTSA.

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  • Cirrhosis alters hemostatic balance, reducing both procoagulant and anticoagulant factors, making traditional tests ineffective for assessing thrombotic risk.
  • This study analyzed coagulation in 30 cirrhotic patients using thrombinography, revealing significantly higher thrombin potential ratios compared to healthy controls, indicating a resistance to activated protein C pathways.
  • Findings suggest that rather than being anticoagulated, cirrhotic patients may experience increased hypercoagulability, especially with advanced disease severity, challenging existing beliefs about their coagulation status.*
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