Publications by authors named "Sapienza P"
Article Synopsis
- - The study analyzed data from over 1.3 million cancer surgery patients in Italy to explore how adherence to cancer screening programs affected early cancer diagnoses before and during the COVID-19 pandemic (2015-2022).
- - Findings showed a significant 45% drop in surgeries during the pandemic, particularly for screenable cancers like breast, colorectal, and cervical cancer, along with a 33.8% reduction in screenings in the first year of COVID-19.
- - The research highlighted that adherence to screening was lower among individuals in rural areas, with low socio-economic status, and those with less education, while organized free screening programs helped reduce these disparities.
Introduction And Importance: Metastatic cancer of the umbilicus is an uncommon and rare presentation.
Case Presentation: Our interest for the clinical outcomes of umbilical metastases from colon cancer arose after a 60-years old lady with ulcerated umbilical lesion came to our clinic. She was seen in several other clinics, and the diagnoses of infection of the umbilical region and/or of umbilical hernia were made.
Background: The aim of our study was to determine a correlation between decrease of levels of atmospheric pollution (as determined by air levels of Particulate Matters with a diameter equal or less to 2.5 microns) and reduced number of hospital admissions and operations for patients with common cardiovascular diseases in Italy.
Methods: We correlated number of hospital admissions and cardiovascular operations and atmospheric levels of PM.
Background: The anatomic variants of the intercostobrachial nerve (ICBN) represent a potential risk of injuries during surgical procedure such as axillary lymph node dissection and sentinel lymph node biopsy in breast cancer and melanoma patients. The aim of this systematic review and meta-analysis was to investigate the different origins and branching patterns of the intercostobrachial nerve also providing an analysis of the prevalence, through the analysis of the literature available up to September 2023.
Materials And Methods: The protocol for this study was registered on PROSPERO (ID: CRD42023447932), an international prospective database for reviews.
Background: The unexpected virulence of the COVID19 pandemic brought to significant changes of generally accepted therapeutic approaches. The consequences of these changes were difficult to define during the pandemic period.
Methods: We analyzed the National Registries including 97% of hospital admissions in Italy, regarding data describing number of operations for aortic valve implantation or repair, carotid and coronary revascularization, AAA repair, and lower limb arterial reconstruction performed in the period 2015 to 2019 and in the pandemic years 2020, 2021, and 2022.
Article Synopsis
- A study was done to understand how often colorectal cancer (CRC) happens after colonoscopies in patients with inflammatory bowel disease (IBD).
- The research found that about 30.8% of IBD patients developed post-colonoscopy CRC within three years, compared to just 6.8% in those without IBD.
- Also, patients with ulcerative colitis had a higher rate of this cancer than those with Crohn's Disease, which means more research is needed to understand why this happens.
Background: the aim of our study was to analyze exposure of the general population to established risk factors for cardiovascular disease (CVD), which might have determined the trend towards increased mortality rates related with CVD from 2015 to 2019 in USA.
Material And Methods: We Analyzed epidemiological of data from the US National Health and Nutrition Examination Survey and from the European Health Interview Survey to determine trends for exposure to several established risk factors for CVD from 2000 to 2018-2019. Trends of prevalence of obesity, arterial hypertension, cigarettes smoking, high cholesterol level, diabetes in the period 2000 to 2018-2019 in USA were correlated with age adjusted mortality and burden related with CVD.
Background: In Europe Cardio Vascular Disease (CVD) mortality rates decreased significantly in the last 25 years, with less decline in the last 5 years. The aim of our study was to analyze trends of risk factors which may explain plateauing of CVD mortality rates in the period 2015-2019 in Europe.
Methods: We analyzed data from the Global Burden Disease and EUROSTAT concerning trends of CVD mortality rates for 25 European countries and simultaneous changes of exposure to risk factors of the population RESULTS: CVD related mortality decreased significantly in the analyzed countries in the period 2000-2015; in the period 2015-2019 there was a trend towards plateauing of CVD related mortality rates, which was associated with an increased exposure to several established risk factors including cigarette smoking, obesity and arterial hypertension.
Background: In this study we correlated changes of risk factors for cardiovascular diseases with trends of age standardized mortality rates and burden for aortic aneurysms and dissections.
Methods: We analyzed data from the Global Burden of Diseases and EUROSTAT.
Findings: There was a significant increase of expenditure for health from 1980 and 2019.
Dealing with acute cholecystitis in high-risk, critically ill, and unfit-for-surgery patients is frequent during daily practice and requires complex management. Several procedures exist to postpone and/or prevent surgical intervention in those patients who temporarily or definitively cannot undergo surgery. After a systematic review of the literature, an expert panel from the Italian Society of Emergency Surgery and Trauma (SICUT) discussed the different issues and statements in subsequent rounds.
View Article and Find Full Text PDFBackground: Temporary intravascular shunts (TIVS) may allow quick revascularization and distal reperfusion, reducing the ischemic time (IT) when an arterial injury occurs. Furthermore, TIVS temporarily restore peripheral perfusion during the treatment of concomitant life-threatening injuries or when patients require evacuation to a higher level of care. Notwithstanding, there are still disputes regarding the use of TIVS, in view of the paucity of evidence in terms of potential benefits and with regard to the anticoagulation during the procedure.
View Article and Find Full Text PDFArticle Synopsis
- Colorectal cancer (CRC) is a major global health issue, frequently causing left bowel obstructions, with CRC responsible for about 50% of these cases, especially in emergency settings.
- The CROSCO-1 study aims to compare different treatment approaches for obstructive left-sided CRC, including emergency surgical resection and staged resection with metallic stents, through a nationwide observational study.
- The primary goal is to assess the 1-year stoma rates between treatment methods, while secondary outcomes include short-term morbidity and mortality, quality of life after a year, and chemotherapy timing, with future studies planned to explore long-term results.
Mixed, nonclassical behavior in a classic allosteric protein.
Proc Natl Acad Sci U S A
September 2023
Allostery is a major driver of biological processes requiring coordination. Thus, it is one of the most fundamental and remarkable phenomena in nature, and there is motivation to understand and manipulate it to a multitude of ends. Today, it is often described in terms of two phenomenological models proposed more than a half-century ago involving only T(tense) or R(relaxed) conformations.
View Article and Find Full Text PDFBackground: This systematic umbrella review aims to investigate and provide an analysis of guidelines regarding the treatment of diverticular abscesses.
Material And Methods: A systematic literature search was performed using the Cochrane Overviews of Reviews model and the 'Clinical Practice Guidelines'; at the end of initial search, only 12 guidelines were included in this analysis. The quality of the guidelines was assessed by adopting the "Appraisal of Guidelines for Research and Evaluation II" (AGREE II).
Background: Knowledge of vascular anatomy and its possible variations is essential for performing embolization or revascularization procedures and complex surgery in the pelvis. The obturator artery (OA) is a branch of the anterior division of the internal iliac artery (IIA), and it has the highest frequency of variation among branches of the internal iliac artery. Possible anomalies of the origin of the obturator artery (OA) should be known when performing pelvic and groin surgery, where its control or ligation may be required.
View Article and Find Full Text PDFBackground: This systematic review aims to investigate whether percutaneous transhepatic gallbladder biliary drainage (PTGBD) is superior to emergency cholecystectomy (EC) as a definitive treatment in high-risk patients with acute cholecystitis (AC).
Material And Methods: A systematic literature search was performed until December 2022 using the Scopus, Medline/PubMed and Web of Science databases.
Results: Seventeen studies have been included with a total of 783,672 patients (32,634 treated with PTGBD vs.