Publications by authors named "Saphira Felicitas Baumgarten"
Front Med (Lausanne)
May 2021
Article Synopsis
- Induced pluripotent stem cells (iPSCs) can be differentiated into various liver cell types, providing a unique opportunity to study liver development, toxicity, and diseases with patient-specific contexts, overcoming limitations imposed by the availability of primary tissues.
- Current research focuses on 3D or organotypic differentiation of iPSCs, creating more realistic models that mimic liver tissue architecture and cell interactions, which could potentially replace animal models in clinical settings.
- A variety of liver organoid models exist, from simple single-cell structures to complex systems that include multiple cell types, enhancing functionality for drug metabolism and disease studies; however, more advanced organotypic models are needed for better disease modeling and therapeutic development.
