Publications by authors named "Sapelli S"
Article Synopsis
- The study evaluated apoptosis in the parotid glands of Wistar rats treated with midazolam, with some groups also receiving pilocarpine.
- Results indicated that rats treated with midazolam alone exhibited a significantly higher apoptotic index compared to control groups treated with saline.
- The addition of pilocarpine reduced the apoptotic effects caused by midazolam, suggesting it may offer some protective benefits against cell death in the glands.
Article Synopsis
- Benzodiazepines (BZDs) can lead to decreased saliva production by affecting the structure of parotid glands, resulting in changes in cell types like acinar, ductal, and myoepithelial cells.
- The study involved 90 male Wistar rats, with different groups receiving varying treatments of BZDs or pilocarpine over 30 to 60 days to observe effects on cell expression.
- Results indicated that lorazepam increased calponin expression in myoepithelial cells, while midazolam combined with pilocarpine enhanced cell proliferation but reduced calponin levels, suggesting that myoepithelial cells might be particularly affected by BZDs.
Background: Myopericytoma is a recently delineated entity showing a hemangiopericytoma-like vascular pattern. This rare mesenchymal neoplasm arises within the subcutaneous tissue of the extremities. Only 3 cases of myopericytoma involving the soft tissues of the mouth have been reported, and this case is the first, to the best of our knowledge, that involves the lips.
View Article and Find Full Text PDFThyroid cancer histotype changes as observed in a major general hospital in a 21-year period.
J Endocrinol Invest
February 1997
The existing registries of thyroid carcinoma are seldom comparable as far as epidemiological data, diagnostic criteria and histopatological description are concerned. Epidemiological studies report a progressive increase in the incidence of thyroid carcinoma in the last twenty years and in both sexes this increase of incidence has been referred to papillary histotype. Data collected from surgical series show a rate of thyroid carcinomas from 7 to 20% of total thyroid surgeries.
View Article and Find Full Text PDFPractolol inhibition of some salbutamol-induced metabolic and hormonal responses.
Acta Diabetol Lat
July 1978
The effect of practolol (a selective beta1-adrenergic receptor blocking agent) on increased blood insulin, sugar, lactate and FFA and decreased blood phosphorus and potassium induced by salbutamol (a primarily beta2-adrenergic stimulant) was studied in 6 normal volunteers. Practolol abolished the rise of lactate and glucose, suggesting that changes in these parameters due to salbutamol are mediated by beta1-receptors. The rise of insulin and the fall of potassium were only partially inhibited, and the possible involvement of the beta2-receptors as well in these 2 cases cannot be ruled out.
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