Publications by authors named "Saowalak Limsaengurai"
Article Synopsis
- Botulinum toxin type A (BoNT-A) has been studied for its potential to lift and remodel skin tissues through intradermal injection, which is hypothesized to produce a lifting effect on the midface.
- The study evaluated various types of BoNT-A (ONA, ABO, PRABO, INCO, and LETI) to see how they affect the contraction of human dermal fibroblasts at different dilutions within a 12-hour period.
- Results showed that while ONA did not alter fibroblast length, other preparations like ABO, PRABO, INCO, and LETI demonstrated varying degrees of contraction depending on dilution, influencing clinical outcomes in facial lifting procedures.
Thai herbal antipyretic 22 formula (APF22), a polyherbal formula, has been traditionally used to treat dermatologic problems including hyperpigmentation. Exposure of the skin to ultraviolet A (UVA) causes abnormal melanin production induced by photooxidative stress. This study thus aimed to investigate the protective effects of APF22 extracts and phenolic compounds, ferulic acid (FA), and gallic acid (GA; used as positive control and reference compounds), on melanogenesis through modulation of nuclear factor E2-related factor 2 (Nrf2) signaling and antioxidant defenses in mouse melanoma (B16F10) cells exposed to UVA.
View Article and Find Full Text PDFDietary phenolics may play a protective role in UV-mediated skin pigmentation through their antioxidant and UV-absorbing actions. In this study, we investigated whether genetic silencing of Nrf2, regulating the transcription of antioxidant genes, affected melanogenesis in primary human epidermal melanocytes (HEMn) and B16F10 melanoma cells subjected to UVA (8J/cm(2)) exposure. Then, we explored the antimelanogenic actions of phenolics; caffeic acid (CA) and ferulic acid (FA) providing partial UVA protection; quercetin (QU) and rutin (RU) providing strong UVA protection and; avobenzone (AV), an efficient UVA filter, in association with modulation of Nrf2-mediated antioxidant defenses in response to UVA insults in B16F10 cells.
View Article and Find Full Text PDFOxidative stress has been suggested to play a role in ultraviolet A (UVA)-mediated melanogenesis. Glutathione (GSH) and GSH-related enzymes including γ-glutamate cysteine ligase (γ-GCL) and glutathione S-transferase (GST) are important antioxidant defenses responsible for maintaining cellular redox balance. Hence, improving GSH redox system to cope with oxidative insults may be essential for attenuation of abnormal melanin production.
View Article and Find Full Text PDF