Publications by authors named "Saori Koh"
Article Synopsis
- The study developed a new mechanistic static pharmacokinetic (MSPK) framework to better predict drug interactions, addressing limitations of existing models that can't use in vitro data or differentiate CYP enzyme contributions.
- By analyzing drug interactions involving multiple CYP isoenzymes and using both in vivo and in vitro data, the researchers could estimate changes in drug concentration and elimination for a wide range of drug combinations.
- The framework proved to be effective in managing drug interactions, illustrating its potential to enhance our understanding of how different drugs might affect each other in the body.
In this study, we developed the drug-drug interaction (DDI) method as a new assessment technique of intestinal availability (F(G), the fraction of drug transferred from the intestinal enterocytes into the liver, escaping from intestinal metabolism) based on the clearance theory. This method evaluates F(G) from changes caused by DDIs in the area under the blood concentration-time curve and in the elimination half-life of victim drugs. Application of the DDI method to data from the literature revealed that the mean and S.
View Article and Find Full Text PDFPurpose: Progressive familial intrahepatic cholestasis type 1 (PFIC1) is a specific form of genetic cholestasis caused by functional defects in FIC1/ATP8B1. Although the way FIC1 deficiency leads to PFIC1 remains unclear, some reports suggest that the loss of FIC1 function results in decreased activity of the farnesoid X receptor (FXR) in PFIC1 patients. In this study, in order to elucidate the molecular mechanism of the pathogenesis of PFIC1, we constructed an experimental system for the evaluation of FIC1-mediated stimulatory effects on FXR activity.
View Article and Find Full Text PDFPurpose: Recently identified organic solute transporter (Ost) alpha and beta are located on the basolateral membrane of enterocytes and may be responsible for the intestinal absorption of many substrates including bile acids. In the present study, the mechanism governing the transcriptional regulation of their expression was investigated.
Methods And Results: To clarify the transcriptional regulation of Osts, reporter gene assays were performed using mouse Ostalpha/beta promoter-luciferase reporter constructs.