Publications by authors named "Saori Kawakami"
Article Synopsis
- The study investigates the genetic causes of early-onset painful peripheral neuropathies related to the SCN9A gene and Nav1.7 sodium channels, focusing on conditions like erythromelalgia and paroxysmal extreme pain disorder.
- Researchers sequenced 18 related genes in eight patients, discovering four specific mutations in the SCN9A gene, including a novel mutation (F1624S).
- Electrophysiological tests confirmed that the F1624S mutation caused significant changes in the behavior of Nav1.7 channels, which helps explain how these mutations contribute to different pain disorders linked to SCN9A.
Background: Panayiotopoulos syndrome (PS) is a common benign epilepsy in childhood, characterized by predominantly autonomic symptoms such as emesis, pallor, and seizures, which are often prolonged. In an emergency room (ER), particularly when unconsciousness is prolonged, differentiating PS from acute encephalopathy is challenging. In this study, we aimed to elucidate the differences in clinical features of patients with PS and acute encephalopathy who visited our ER.
View Article and Find Full Text PDFIsolated cranial neuritis of the oculomotor nerve: Expanding the MOG phenotype?
Mult Scler Relat Disord
June 2020
Article Synopsis
- Autoantibodies against myelin oligodendrocyte glycoprotein (MOG) have been linked to various neurological disorders, with recent findings highlighting new conditions associated with MOG-IgG.
- A pediatric patient diagnosed with isolated oculomotor neuritis showed MOG-IgG positivity, despite no other central nervous system lesions on MRI, showcasing a rare presentation of the condition.
- This case suggests that MOG-IgG may play a role in isolated cranial nerve lesions, indicating that clinicians should consider testing for MOG-IgG when symptoms of cranial neuritis are present.
Background: Pedicled flaps are useful for reconstructive surgery. Previously, we often used vascularized supraclavicular flaps, especially for head and neck reconstruction, but then shifted to using thoracic branch of the supraclavicular artery (TBSA) flaps. However, limited research exists on the anatomy of TBSA flaps and on the use of indocyanine green (ICG) fluorescence videoangiography for supraclavicular artery flaps.
View Article and Find Full Text PDFA high prevalence of pain and difficulties with pain assessment has been widely reported among residents of long-term-care facilities. We explored nurses' and care workers' estimations of residents' pain (both general and chronic) and the number of residents with unknown pain status. We also examined the relationship between the prevalence of pain and assessment strategies undertaken by nurses and care workers.
View Article and Find Full Text PDFBackground: The pathophysiologic features of acute respiratory distress syndrome (ARDS) are attributed to neutrophil accumulation and over-activation. Low blood immunoglobulin G concentrations in septic shock patients are associated with higher risk of developing ARDS. This study showed the effects of intravenous immunoglobulin (IVIg) on neutrophil apoptosis and accumulation in the lung during murine endotoxemia.
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