Publications by authors named "Saori Ikumi"
Background: Currently, clinical indicators for evaluating endothelial permeability in sepsis are unavailable. Endothelium-derived extracellular vesicles (EDEVs) are emerging as biomarkers of endothelial injury. Platelet endothelial cell adhesion molecule (PECAM) and vascular endothelial (VE)-cadherin are constitutively expressed endothelial intercellular adhesion molecules that regulate intercellular adhesion and permeability.
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- Sodium-glucose cotransporter 2 inhibitors (SGLT2is) are common diabetes medications that can lead to ketoacidosis, prompting this study to explore their incidence in surgical patients.
- A multicenter study in Japan tracked surgical patients on SGLT2is to identify occurrences of perioperative ketoacidosis, defined by specific urine and blood criteria, over a monitoring period after surgery.
- The findings showed that only 0.40% of patients exhibited symptoms consistent with ketoacidosis, but all cases were due to respiratory acidosis, leading to an estimated SGLT2i-associated ketoacidosis rate of 0%, suggesting a lower risk than anticipated.
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- Ischemic heart disease is a major global health issue, with coronary artery bypass grafting (CABG) being a common treatment, and landiolol is a beta-antagonist believed to reduce postoperative complications like atrial fibrillation.
- This study analyzed data from a large cohort of CABG patients between 2010 and 2020, comparing those given landiolol during surgery to those who weren't, focusing on their in-hospital mortality rates.
- Results indicated that patients who received intraoperative landiolol had a significantly lower in-hospital mortality rate (3.7%) compared to those in the control group (4.3%), suggesting that landiolol may improve outcomes for CABG patients, although further research
Background: Japan has four types of intensive care units (ICUs) that are divided into two categories according to the management fee charged per day: ICU management fees 1 and 2 (ICU1/2) (equivalent to high-intensity staffing) and 3 and 4 (ICU3/4) (equivalent to low-intensity staffing). Although ICU1/2 charges a higher rate than ICU3/4, no cost-effectiveness analysis has been performed for ICU1/2. This study evaluated the clinical outcomes and cost-effectiveness of ICU1/2 compared with those of ICU3/4.
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- The study aimed to examine the changing mortality rates of COVID-19 patients in Japan across six waves, with a focus on age groups and risk levels.
- A total of 56,986 patients were analyzed, categorized by age and a mortality risk score, revealing significant differences in mortality rates compared to the UK.
- Results indicated that while Japanese patients generally had lower mortality rates than those in the UK, older patients (≥75 years) at very high risk experienced similar rates during the fourth and fifth waves, but showed improved survival in the sixth wave.
Monitoring the pain intensity in critically ill patients is crucial because intense pain can cause adverse events, including poor survival rates; however, continuous pain evaluation is difficult. Vital signs have traditionally been considered ineffective in pain assessment; nevertheless, the use of machine learning may automate pain assessment using vital signs. This retrospective observational study was performed at a university hospital in Sendai, Japan.
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