Microwave-Assisted Synthesis of 5'--methacryloylcytidine Using the Immobilized Lipase Novozym 435.

Nucleobase building blocks have been demonstrated to be strong candidates when it comes to DNA/RNA-like materials by benefiting from hydrogen bond interactions as physical properties. Modifying at the 5' position is the simplest way to develop nucleobase-based structures by transesterification using the lipase Novozym 435. Herein, we describe the optimization of the lipase-catalyzed synthesis of the monomer 5'--methacryloylcytidine with the assistance of microwave irradiation.

Optimization of the Microwave Assisted Glycosylamines Synthesis Based on a Statistical Design of Experiments Approach.

Glycans carry a vast range of functions in nature. Utilizing their properties and functions in form of polymers, coatings or glycan derivatives for various applications makes the synthesis of modified glycans crucial. Since amines are easy to modify for subsequent reactions, we investigated regioselective amination conditions of different saccharides.

Functional Glyco-Nanogels for Multivalent Interaction with Lectins.

Interactions between glycans and proteins have tremendous impact in biomolecular interactions. They are important for cell-cell interactions, proliferation and much more. Here, we emphasize the glycan-mediated interactions between pathogens and host cells.

Novel Fully Organic Water Oxidation Electrocatalysts: A Quest for Simplicity.

Despite the growing need for readily available and inexpensive catalysts for the half-reactions involved in water splitting, water oxidation and reduction electrocatalysts are still traditionally based on noble metals. One long-standing challenge has been the development of an oxygen evolution reaction catalyzed by easily available, structurally simple, and purely organic compounds. Herein, we first generalize the performance of the known -ethyl-flavinium ion to a number of derivatives.