[Dimethylarsinous acid-promoted skin tumorigenesis through the induction of oxidative stress in mice].

Objective: To investigated the relationship between skin-tumor promotion and oxidative stress caused by dimethylated arsenic in mice.

Methods: The experimental animal model was used to examine the effect of dimethylated arsenic, a metabolite of DMA(V), dimethylarsinous acid (DMA(III)) in skin tumorigenesis in mice. The 8-oxo-2'-deoxyguanosine (8-oxodG) analysis of epidermis was based on the method of HPLC.

[Inhibition of (-)epigallocatechin gallate on dimethylarsinic acid promoting lung tumorigenesis through the induction of oxidative stress in mice].

Objective: To investigate inhibition of ((-)epigallocatechin gallate, EGCG) on lung-tumor promotion and oxidative stress caused by administration of dimethylarsinic acid (DMA(V)) in mice.

Methods: The experimental animal model, which is induced by lung tumor initiator (4NQO) and promoter (DMA(V)) in mice, was used to examine the effect of EGCG on DMA(V) promoting lung tumorigenesis. The 8-oxo-2'-deoxyguanosine (8-oxodG) analysis of lungs were used of HPLC.

[Investigation and analysis of neonate deformity in water arsenic exposure areas].

Objective: To explore the level and feature of neonate deformity in water arsenic exposure areas, as to finding out an evidence for the study and prevention of the arsenic exposure.

Methods: The birth situation of neonate was surveyed from 1998 to 2004 in water arsenic exposure areas according to cross-sectional survey. The results were classified in accordance with ICD-10 and common surveillance of china.

[An overview on biomarkers of arsenic-induced health hazardsan].

A series of molecular environmental epidemiological studies have been carried out to elucidate biomarkers of exposure, effect, and susceptibility for arsenic-related health hazards in Taiwan area in China. Arsenic levels in urine, hair, and nail could be biomarkers for short-term internal dose, skin hyperpigmentation and palmoplantar hyperkeratosis could be biomarkers for long-term (many years) internal dose, and percentage of monomethylarsonic acid in total metabolites of inorganic arsenic in urine could be considered as an exposure marker for biologically effective dose. The biomarkers of early biological effects of ingested inorganic arsenic could include blood levels of reactive oxidants and antioxidant capacity, genetic expression of inflammatory molecules, as well as cytogenetic changes including sister chromatid exchange, micronuclei, and chromosome aberrations of peripheral lymphocytes.

Arsenic and fluoride exposure in drinking water: children's IQ and growth in Shanyin county, Shanxi province, China.

Background: Recently, in a cross-sectional study of 201 children in Araihazar, Bangladesh, exposure to arsenic (As) in drinking water has been shown to lower the scores on tests that measure children's intellectual function before and after adjustment for sociodemographic features.

Objectives: We investigated the effects of As and fluoride exposure on children's intelligence and growth.

Methods: We report the results of a study of 720 children between 8 and 12 years of age in rural villages in Shanyin county, Shanxi province, China.