Aquatic geochemistry of a major freshwater lake in the Kashmir Himalaya: solute acquisition and denudation process in the lacustrine system.

Lakes, the main entities of lacustrine environments, are a rich archive of environmental and geogenic changes in terms of compositional variation of water and sediment. Water and sediment samples (N = 173) were collected during 2013-2014 from the Wular Lake, one of the important fresh lakes within the Indian landmass. The study provides insights on the solutes acquisition mechanism and provenance of ionic constituents within the lake water and the sediments.

Top quark asymmetry and Wjj excess at CDF from gauged flavor symmetry.

We show that the scalar sector needed for fermion mass generation when the flavor symmetry of the standard model is maximally gauged can consistently explain two anomalies reported recently by the CDF Collaboration-the forward-backward asymmetry in tt pair production and the dijet invariant mass in the Wjj channel. A pair of nearly degenerate scalar doublets with masses in the range 150-200 GeV explain these anomalies, with additional scalars predicted in the mass range 100-400 GeV. Consistency of such low scale flavor physics with flavor-changing processes is shown, and expectations for the LHC are outlined.

Rapid in vitro production of cloned plants of Uraria picta (Jacq.) DC-A rare medicinal herb in long-term culture.

An efficient in vitro process for rapid production of cloned plants of Uraria picta has been developed employing nodal stem segments taken from field-grown plants. Explants showed bud-break followed by regeneration of shoots with restricted growth within 12 days on modified Murashige and Skoog's medium supplemented with 0.25 mg l(-1) each of 6-benzylaminopurine and indole-3-acetic acid and 25 mg l(-1) adenine sulfate.

Inhibitory effect of novel diallyldisulfide analogs on HMG-CoA reductase expression in hypercholesterolemic rats: CREB as a potential upstream target.

Aims: Diallyldisulfide (DADS), an active principle of garlic (Allium sativum) is known for its antihyperlipidemic properties. The present study was designed to evaluate the effect of novel synthesized DADS analogs, on the lipid profile of hypercholesterolemic rats and to investigate the molecular correlates of their activity at the cellular level.

Main Methods: Wistar rats, weighing 100-120 g each, were administered with 5% cholesterol for one week, and subsequently administered with lovastatin, allicin and DADS (20 mg/kg wt) analogs in the second week along with 5% cholesterol.

Synthesis and pharmacological evaluation of new arylpiperazines N-[4-[4-(aryl) piperazine-1-yl]-phenyl]-amine derivatives: putative role of 5-HT1A receptors.

In an attempt to design novel 5-HT(1A) agonists/partial agonists, based on an arylpiperazine nucleus, a series of N-{4-[4-(aryl)piperazine-1-yl]-phenyl}-amine derivatives were synthesized and biologically tested. The anxiolytic effect of the compounds was investigated employing the Elevated plus Maze (EPM) task. On the basis of in vivo functional test, compound 1c (3mg/kg) and 4c (3mg/kg) induced significant increments in open arm entries and time on EPM as compared to Buspirone.

Signatures for right-handed neutrinos at the large hadron collider.

We explore possible signatures for right-handed neutrinos in a TeV scale B-L extension of the standard model at the Large Hadron Collider. The studied four lepton signal has a tiny standard model background. We find the signal experimentally accessible at the LHC for the considered parameter regions.

The effect of the aqueous extract of the roots of Asparagus racemosus on hepatocarcinogenesis initiated by diethylnitrosamine.

Histopathological studies of the hepatic tissues of Wistar rats treated with diethylnitrosamine (DEN) (200 mg/kg b wt, i.p.) once a week for 2 weeks, followed by treatment with DDT, a tumor promoter (0.

Synthesis, DNA binding, and cytotoxic evaluation of new analogs of diallyldisulfide, an active principle of garlic.

Diallyldisulfide (DADS), an active principle of garlic (Allium sativum) is known for its antihyperlipidemic properties. However, its use is limited due to its extreme volatility. In the present study, we have synthesized and characterized a series of six new DADS analogs and investigated their interactions with different DNA duplexes.

Effect of hyperhomocysteinemia on cardiovascular risk factors and initiation of atherosclerosis in Wistar rats.

Hyperhomocysteinemia is considered an independent risk factor for atherosclerosis. The present study was designed to assess the effect of high level of serum homocysteine on other cardiovascular risk factors and markers in rats and to study its mode of action in initiating atherosclerosis. To address this issue, four different doses of methionine (0.