Publications by authors named "Santosh Gothwal"
Article Synopsis
- - Efficient repair of DNA double-strand breaks in B-cell antibody class switch recombination (CSR) is influenced by the histone acetyl reader BRD2, which helps direct the repair process towards nonhomologous end joining (NHEJ) and minimizes errors.
- - BRD2 deficiency disrupts the necessary synapse formation between switch (S) regions and impairs the DNA damage response, leading to increased DNA break end resection and a potential increase in aberrant recombination events.
- - The study highlights the role of BRD2 and its stability with the cohesion loader protein NIPBL, indicating that their loss can hinder CSR and is relevant in understanding conditions like Cornelia de Lange syndrome that also involve
Homologous recombination is essential for chromosome segregation during meiosis I. Meiotic recombination is initiated by the introduction of double-strand breaks (DSBs) at specific genomic locations called hotspots, which are catalyzed by Spo11 and its partners. DSB hotspots during meiosis are marked with Set1-mediated histone H3K4 methylation.
View Article and Find Full Text PDFRadiation processing of soybean, varying in seed coat colour, was carried out at dose levels of 0.25, 0.5 and 1 kGy to evaluate their potential anti-proliferative and cytoprotective effects in an in vitro cell culture system.
View Article and Find Full Text PDFHistone modification is a critical determinant of the frequency and location of meiotic double-strand breaks (DSBs), and thus recombination. Set1-dependent histone H3K4 methylation and Dot1-dependent H3K79 methylation play important roles in this process in budding yeast. Given that the RNA polymerase II associated factor 1 complex, Paf1C, promotes both types of methylation, we addressed the role of the Paf1C component, Rtf1, in the regulation of meiotic DSB formation.
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