Publications by authors named "Santos A Acosta"
Article Synopsis
- The rise of antibiotic resistance highlights the urgent need for new antibiotic discovery methods, leading to the identification of Symbah-1, a synthetic peptide antibiotic from a high-throughput screen.
- Symbah-1 targets bacteria through membrane disruption and is effective against various drug-resistant pathogens, exhibiting a specific β-hairpin structure influenced by lipopolysaccharide.
- Although originally less effective in human serum, modifications of Symbah-1 led to variants with improved serum activity and resistance to proteases, suggesting the potential for designing synthetic peptide libraries to explore this unique class of antibiotics further.
