Publications by authors named "Santiago Sanchez-Alonso"
Unlabelled: The Canary Islands inhabitants, a recently admixed population with significant North African genetic influence, has the highest incidence of childhood-onset type 1 diabetes (T1D) in Spain and one of the highest in Europe. HLA accounts for half of the genetic risk of T1D.
Aims: To characterize the classical HLA-DRB1 and HLA-DQB1 alleles in children from Gran Canaria with and without T1D.
COVID-19 has overloaded national health services worldwide. Thus, early identification of patients at risk of poor outcomes is critical. Our objective was to analyse SARS-CoV-2 RNA detection in serum as a severity biomarker in COVID-19.
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- SARS-CoV-2 triggers a strong immune response, which is crucial in determining how severe COVID-19 becomes in patients.
- Analysis of blood samples from 276 patients showed that severe cases were linked to a drop in key immune cells (T, B, and NK cells) and changes in specific immune cell types.
- The study highlights the association between severity and a weakened humoral immune response, with implications for developing new treatment strategies for COVID-19.
Background: Patients with coronavirus disaese 2019 (COVID-19) can develop a cytokine release syndrome that eventually leads to acute respiratory distress syndrome requiring invasive mechanical ventilation (IMV). Because IL-6 is a relevant cytokine in acute respiratory distress syndrome, the blockade of its receptor with tocilizumab (TCZ) could reduce mortality and/or morbidity in severe COVID-19.
Objective: We sought to determine whether baseline IL-6 serum levels can predict the need for IMV and the response to TCZ.
Background: Lung cancer is one of the most frequent malignancies in humans and is a major cause of death. A number of therapies aimed at reinforcing antitumor immune response, including antiprogrammed cell death protein 1 (anti-PD-1) antibodies, are successfully used to treat several neoplasias as non-small cell lung cancer (NSCLC). However, host immune mechanisms that participate in response to anti-PD-1 therapy are not completely understood.
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- SARS-CoV-2 causes COVID-19, which can range from mild symptoms to severe acute respiratory distress syndrome (ARDS) characterized by inflammation and immune dysregulation in patients.
- The study investigates specific immune cell subsets, including dendritic cells and monocytes, in COVID-19 patients of varying severity, comparing them to healthy individuals.
- Findings reveal that certain inflammatory monocytes and dendritic cells, particularly CD1c+ types, are more prevalent in the lungs of severe COVID-19 patients, contributing to a better understanding of the disease mechanism and potential treatments.
The SARS-CoV-2 is responsible for the pandemic COVID-19 in infected individuals, who can either exhibit mild symptoms or progress towards a life-threatening acute respiratory distress syndrome (ARDS). It is known that exacerbated inflammation and dysregulated immune responses involving T and myeloid cells occur in COVID-19 patients with severe clinical progression. However, the differential contribution of specific subsets of dendritic cells and monocytes to ARDS is still poorly understood.
View Article and Find Full Text PDFMyocardial ischemia-related disorders constitute a major health problem, being a leading cause of death in the world. Upon ischemia, tissue remodeling processes come into play, comprising a series of inter-dependent stages, including inflammation, cell proliferation and repair. Neovessel formation during late phases of remodeling provides oxygen supply, together with cellular and soluble components necessary for an efficient myocardial reconstruction.
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