Systematic review of economic evaluation analyses of available vaccines in Spain from 1990 to 2012.

Objective: The objective of this survey was to describe the evolution of economic evaluation studies on vaccines available in Spain.

Methods: We conducted a systematic review of the economic evaluations published by Spanish researchers in major bibliographic databases available online from 1990 to 2012. For all references identified, we limited them to full economic evaluation carried out in Spanish vaccine programs.