Publications by authors named "Santiago Noriega"
Article Synopsis
- Neurons experience high levels of single-strand DNA breaks (SSBs) at enhancer regions, but the exact cause of this damage was previously unknown.
- Research shows that thymidine DNA glycosylase (TDG) acts on oxidized methylcytosines, leading to these SSBs, particularly in both neurons and transdifferentiated macrophages.
- While macrophages prefer short-patch repair for DNA gaps, neurons often utilize long-patch repair; disruption of this process can cause DNA damage and neuronal cell death, indicating a link between active DNA demethylation and neurotoxicity during cancer treatment.
