Publications by authors named "Santiago Navas-Carretero"

Introduction: Glucose homeostasis may be dependent on liver conditions and influence health-related markers and quality of life (QoL) objective measurements. This study aimed to analyze the interactions of glycemia with liver and health status in a prediabetic population.

Subjects And Methods: This study included 2220 overweight/obese prediabetics from the multinational PREVIEW project.

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Objectives: Childhood obesity continues to rise worldwide. Family gut microorganisms may be associated with childhood obesity. The aim of the study was to analyze bacterial similarities in fecal microbiota composition between parent-offspring pairs as linked to body weight.

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Article Synopsis
  • * Researchers conducted a 2-month controlled trial with Spanish children who followed a structured meal plan featuring healthy foods and monitored diet quality using the KIDMED index.
  • * Results showed that 12 significant metabolites related to protein and lipid metabolism decreased after the intervention, indicating improved diet quality and effectiveness of the ALINFA program.
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Background: Lifestyle interventions can prevent type 2 diabetes (T2D) by successfully inducing behavioral changes (eg, avoiding physical inactivity and sedentariness, increasing physical activity and/or healthy eating) that reduce body weight and normalize metabolic levels (eg, HbA1c). For interventions to be successful, it is important to influence "behavioral mechanisms" such as self-efficacy, which motivate behavioral changes. Theory-based expectations of how self-efficacy, chronic stress, and mood changed over time were investigated through a group-based behavior change intervention (PREMIT).

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Objectives: Innovative precision dietary procedures are required to promote healthy aging. This study aimed to evaluate the effects of a personalised strategy based on the inclusion of individualised foods and digital tools on overall health status and quality of life within a follow-up of 3 months in older adults with overweight or obesity.

Methods: 127 men and women aged between 50 and 80 years with overweight/obesity participated in the study-between January 2020 and September 2020 at the Center for Nutrition Research-University of Navarra and IMDEA-ALIMENTACIÓN-and were randomly assigned to a usual-care group (standard recommendations) or precision group (precision nutrition strategy based on the inclusion of individualised foods and a mobile application).

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This study aimed to investigate if the duration of breastfeeding and the method at initiation of complementary feeding affect eating behaviour in children aged 3-6 years. This is a cross-sectional analysis from the Childhood Obesity Risk Assessment Longitudinal Study project, an ongoing longitudinal cohort study that aims to identify childhood obesity risk factors in Spanish children. A total of 1215 children aged 3-6 years were included.

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Food patterns are deteriorating and, consequently, not meeting nutritional recommendations. Learning about the adherence to a diet is crucial for understanding children's dietary habits. The objective of the present analysis was to assess the degree of compliance with the ALINFA nutritional intervention and the effectiveness of adherence groups, and to evaluate potential baseline factors predicting a higher adherence to the intervention.

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Importance: High intake of ultraprocessed foods (UPFs) has been associated with higher cardiometabolic risk in adults; however, the evidence in children is limited.

Objective: To investigate the association between UPF consumption and cardiometabolic risk factors in the Childhood Obesity Risk Assessment Longitudinal Study (CORALS).

Design, Setting, And Participants: This baseline cross-sectional analysis was conducted using the data of CORALS participants recruited between March 22, 2019, and June 30, 2022.

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Article Synopsis
  • - The study explored how different sweeteners (like Stevia and Neotame) in biscuits affect appetite and hormone responses compared to regular sugar (sucrose) in adults with overweight or obesity.
  • - Participants consumed biscuits with varying sweeteners over two-week periods; results showed that all formulations similarly reduced appetite, but Neotame and Stevia led to lower insulin levels after eating compared to sugar.
  • - Overall, replacing sugar with these sweeteners had no significant impact on appetite or hormonal responses over time, although they did help in lowering post-meal insulin and glucose levels.
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Self-report and device-based measures of physical activity (PA) both have unique strengths and limitations; combining these measures should provide complementary and comprehensive insights to PA behaviours. Therefore, we aim to 1) identify PA clusters and clusters of change in PA based on self-reported daily activities and 2) assess differences in device-based PA between clusters in a lifestyle intervention, the PREVIEW diabetes prevention study. In total, 232 participants with overweight and prediabetes (147 women; 55.

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Objective: To examine whether eating behavior and perceived stress predict the maintenance of self-reported dietary change and adherence to dietary instructions during an intervention.

Design: A secondary analysis of the behavior maintenance stage (6-36 months) of the 3-year PREVIEW intervention (PREVention of diabetes through lifestyle Intervention and population studies in Europe and around the World).

Participants: Adults (n = 1,311) with overweight and prediabetes at preintervention baseline.

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To assess the associations between the adherence to a composite score comprised of 6 healthy lifestyle behaviors and its individual components with several cardiometabolic risk factors in Spanish preschool children. Cross-sectional analyses were conducted in 938 participants included in the CORALS cohort aged 3-6 years. Six recognized healthy lifestyle behaviors (breastfeeding, sleep duration, physical activity, screentime, adherence to the Mediterranean diet, and eating speed) were assessed in a composite score.

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Article Synopsis
  • Sleep duration is linked to overweight/obesity risk and may influence liver health, particularly fatty liver in children and adolescents aged 2-18, studied through various measurements in a sample of 854 participants.
  • Higher hepatic steatosis index, a marker for fatty liver, is associated with obesity compared to overweight conditions, with pear-shaped body fat distribution potentially worsening liver fat accumulation.
  • The study found that sleep time can mediate the relationship between body fat distribution and liver health, suggesting improving sleep may help manage fatty liver disease in youth.
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  • * In a review of clinical trials, only two out of five showed significant changes in gut microbiota from NNSs like saccharin and sucralose, with these sweeteners possibly worsening glycemic tolerance.
  • * Evidence from three out of four cross-sectional studies suggested a link between NNSs and gut microbiota composition, while clinical trials on polyols showed positive prebiotic effects, yet these studies had limitations that compromise their reliability.
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Unlabelled: A reliable food and beverage frequency questionnaire (F&B-FQ) to measure dietary intakes for children across Spain is currently unavailable. Thus, we designed and assessed the reproducibility and relative validity of a new F&B-FQ in 210 Spanish children aged 3-11 years. COME-Kids F&B-FQ contained 125 items to assess the usual diet intake in the past year among children.

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Background/objectives: Some individuals with overweight/obesity may be relatively metabolically healthy (MHO) and have a lower risk of cardiovascular disease than those with metabolically unhealthy overweight/obesity (MUO). We aimed to compare changes in body weight and cardiometabolic risk factors and type 2 diabetes incidence during a lifestyle intervention between individuals with MHO vs MUO.

Methods: This post-hoc analysis included 1012 participants with MHO and 1153 participants with MUO at baseline in the randomized trial PREVIEW.

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The study aimed to evaluate the efficacy of a new nutritional intervention, focused on improving the quality of the diet in children aged 6 to 12 years. A 2-month parallel, controlled randomized trial was conducted in the Spanish child population. The children were randomized to ALINFA nutritional intervention, which consisted of a normocaloric diet that incorporates products, ready-to-eat meals and healthy recipes specifically designed for the study, or a control group, which received the usual advice on healthy eating.

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Portion control tableware has been described as a potentially effective approach for weight management, however the mechanisms by which these tools work remain unknown. We explored the processes by which a portion control (calibrated) plate with visual stimuli for starch, protein and vegetable amounts modulates food intake, satiety and meal eating behaviour. Sixty-five women (34 with overweight/obesity) participated in a counterbalanced cross-over trial in the laboratory, where they self-served and ate a hot meal including rice, meatballs and vegetables, once with a calibrated plate and once with a conventional (control) plate.

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Article Synopsis
  • - The study aimed to investigate how HbA (hemoglobin A1c) and glucose-related factors influence weight loss and blood sugar changes after an 8-week low energy diet in people with overweight and pre-diabetes conditions.
  • - In a sample of 2,178 individuals, neither HbA levels nor certain glucose measures correlated with changes in body weight after the diet; however, factors like higher body weight and insulin levels were linked to improved fasting glucose levels.
  • - The findings suggest that while HbA and glucose do not predict short-term weight loss success, they may affect metabolic responses to rapid weight loss, highlighting the roles of inflammation and body fat in these processes.
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Project SWEET examined the barriers and facilitators to the use of non-nutritive sweeteners and sweetness enhancers (hereafter "S&SE") alongside potential risks/benefits for health and sustainability. The Beverages trial was a double-blind multi-centre, randomised crossover trial within SWEET evaluating the acute impact of three S&SE blends (plant-based and alternatives) vs. a sucrose control on glycaemic response, food intake, appetite sensations and safety after a carbohydrate-rich breakfast meal.

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Article Synopsis
  • - The study investigates the effects of consuming non-nutritive sweeteners and sweetness enhancers (S&SEs) on appetite and related health outcomes, particularly focusing on how acute versus repeated intake influences these factors in food consumption.
  • - Conducted as part of the SWEET Project, the research includes five double-blind trials with 213 participants across Europe, comparing traditional sugar-sweetened products to those reformulated with S&SEs in various food forms.
  • - Ethical approvals have been obtained, and findings will be shared in open-access journals and an online research data archive, ensuring transparency and accessibility of the results.
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Background: To better support participants to achieve long-lasting results within interventions aiming for weight loss and maintenance, more information is needed about the maintenance of behavioral changes. Therefore, we examined whether perceived stress predicts the maintenance of changes in eating behavior (flexible and rigid restraint of eating, disinhibition, and hunger).

Methods: The present study was a secondary analysis of the PREVIEW intervention including participants with overweight (BMI ≥ 25 kg/m) at baseline and high risk of type 2 diabetes (n = 1311).

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Article Synopsis
  • The study aims to evaluate the effects of consuming sweeteners and sweetness enhancers (S&SEs) within a healthy diet on weight loss maintenance and obesity-related health factors compared to sugar.
  • It involves over 330 adults and 40 children, starting with a low-energy diet for adults to achieve weight loss, followed by a 10-month phase where participants are randomly assigned to diets with or without S&SEs.
  • The trial is ethically approved and will assess various health outcomes, including body weight, gut microbiota, and risk markers for type-2 diabetes and cardiovascular diseases through clinical investigations at multiple time points. *
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Article Synopsis
  • The study focused on understanding the relationship between gut microbiota and quality of life in individuals aged 50-80.
  • Researchers analyzed fecal samples and utilized the SF-36 questionnaire to assess quality of life, finding specific bacteria linked to higher or lower scores.
  • Actinobacteria was positively associated with better quality of life, while Peptostreptococcaceae was linked to poorer quality, suggesting that gut bacteria could help predict overall well-being in older adults.
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