Publications by authors named "Santiago Justo Arevalo"
The COVID-19 pandemic has highlighted the importance in the understanding of the biology of SARS-CoV-2. After more than two years since the first report of COVID-19, it remains crucial to continue studying how SARS-CoV-2 proteins interact with the host metabolism to cause COVID-19. In this review, we summarize the findings regarding the functions of the 16 non-structural, 6 accessory and 4 structural SARS-CoV-2 proteins.
View Article and Find Full Text PDFAt over 0.6% of the population, Peru has one of the highest SARS-CoV-2 mortality rate in the world. Much effort to sequence genomes has been done in this country since mid-2020.
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- Hepatitis B virus (HBV) is found globally and has ten genotypes, with genotype H being prominent in Mexico and possibly originating there, particularly among indigenous populations.
- The study aimed to determine the age of HBV genotype H in Mexico using molecular dating techniques, analyzing 92 sequences, including 48 from genotype H.
- Results estimated genotype H in Mexico to be around 2070.9 years old, with four significant diversification events identified, and confirmed the divergence of genotype H from genotype F approximately 8140.8 years ago.
Article Synopsis
- Understanding how cyanide-degrading bacteria work can help improve methods for cleaning up cyanide pollution, which is important for both health and industry.
- Researchers isolated a strain called Bacillus safensis PER-URP-08 from mine tailings in Peru and found a gene for an enzyme (CynD) that helps break down cyanide, showing it works well even at higher pH levels.
- The study highlights the need for further investigation into using Bacillus safensis PER-URP-08 and its CynD enzyme as effective tools for bioremediation, emphasizing the importance of addressing cyanide's environmental impacts on a global scale.
The recent outbreak of yellow fever (YF) in São Paulo during 2016-2019 has been one of the most severe in the last decades, spreading to areas with low vaccine coverage. The aim of this study was to assess the genetic diversity of the yellow fever virus (YFV) from São Paulo 2016-2019 outbreak, integrating the available genomic data with new genomes from patients from the Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (HCFMUSP). Using phylodynamics, we proposed the existence of new IE subclades, described their sequence signatures, and determined their locations and time of origin.
View Article and Find Full Text PDFCoronavirus disease 2019 (COVID-19) is a contagious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This disease has spread globally, causing more than 161.5 million cases and 3.
View Article and Find Full Text PDFSince the identification of SARS-CoV-2, a large number of genomes have been sequenced with unprecedented speed around the world. This marks a unique opportunity to analyze virus spreading and evolution in a worldwide context. Currently, there is not a useful haplotype description to help to track important and globally scattered mutations.
View Article and Find Full Text PDFThe second messenger cyclic diguanylate monophosphate (c-di-GMP) is a central regulator of bacterial lifestyle, controlling several behaviors, including the switch between sessile and motile states. The c-di-GMP levels are controlled by the interplay between diguanylate cyclases (DGCs) and phosphodiesterases, which synthesize and hydrolyze this second messenger, respectively. These enzymes often contain additional domains that regulate activity via binding of small molecules, covalent modification, or protein-protein interactions.
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