Publications by authors named "Santiago Jimenez Valero"

Background: Obstructive complications in the Fontan circulation pose significant risks to affected patients. Traditional management strategies may be insufficient, necessitating innovative treatment approaches. This case report discusses the use of the FlowTriever Retrieval System for percutaneous aspiration thrombectomy in a patient with a history of Fontan procedure who developed conduit obstruction due to thrombus formation.

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Article Synopsis
  • Bicuspid aortic valve (BAV) is a common congenital heart condition affecting 0.5-2% of the population and is linked to higher incidences in patients with severe aortic stenosis and older adults undergoing surgery.
  • Transcatheter aortic valve replacement (TAVR) is a new treatment option for aortic stenosis, but there's insufficient evidence to identify the best approach for patients with BAV.
  • The report discusses a case of severe acute recoil after TAVR with a self-expanding prosthesis in a patient with heavily calcified BAV and reviews the implications of prosthesis underexpansion in the medium term.
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Transcatheter heart valve embolization is a serious and rare complication of transcatheter aortic valve replacement. Having a strategy for promptly managing transcatheter heart valve embolization is crucial to avoid emergency conversion from transcatheter aortic valve replacement to open-heart surgery. Many cases of transcatheter heart valve embolization occurring with balloon-expandable prostheses such as the SAPIEN 3 (Edwards LifeSciences Corporation) valve and self-expandable prostheses such as the ACURATE neo (Boston Scientific Corporation) valve have been reported in the literature.

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Through these clinical cases, we present a new protocol of action, updated with the latest evidence on percutaneous pulmonary thrombectomy using dedicated catheters, for high-risk PE in pregnant women or during the early postpartum period.

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  • Covered stents (CS), originally used for coronary perforation, are now being studied for their effectiveness in treating coronary aneurysms (CAA), although data on long-term outcomes is limited.
  • This meta-analysis evaluates major adverse cardiac events (MACE) in patients treated with the new PK Papyrus CS over an average follow-up of 16.2 months, analyzing data from three observational trials.
  • Results show a MACE rate of 14.3%, with higher rates in CAA patients compared to those with coronary perforation, highlighting the need for careful patient selection and treatment optimization for better outcomes.
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Background: High-risk Pulmonary Embolism (PE) mortality remains very high. Systemic thrombolysis is effective but carries significant complications and contraindications related to the hemorrhagic risk. Percutaneous thrombectomy using aspiration catheters may be an alternative in patients with a high bleeding risk.

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The usefulness of drug-eluting balloons (DEBs) has not been fully elucidated in calcified coronary lesions (CCLs). This meta-analysis aimed to evaluate the efficacy of DEBs compared to a drug-eluting stent (DES) in this setting. PubMed, EMBASE and Cochrane were searched through December 2023.

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Background: Previous studies have documented a high rate of implantation success with the ACURATE neo2 valve, as well as a reduction in paravalvular leak (PVL) compared to its predecessor, the ACURATE neo. However, there are no studies that have reviewed and compared the long-term clinical and hemodynamic outcomes of these patients.

Aims: This study aimed to evaluate the results of the ACURATE neo transcatheter aortic valve in a real-world context, and to compare the results of the outcomes of both generations of this device (ACURATE neo and ACURATE neo2), with a specific focus on procedural success, safety, and long-term effectiveness.

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Dynamic road-mapping (DRM) (Dynamic Coronary Roadmap; Philips) offers a real-time, dynamic overlay of the coronary tree on fluoroscopy.

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A 69-year-old man who underwent a liver transplant in 2014 due to hepatitis C virus hepatopathy was evaluated for dyspnea on exertion and chest pain.

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Objectives: The aim of this study was to analyze the efficacy and safety of percutaneous balloon pericardiotomy (PBP) in oncological patients who present with a malignant pericardial effusion (MPE).

Background: The use of PBP as a treatment for MPE is not standardized due to the limited evidence. Furthermore, the performance of a second PBP for a recurrence after a first procedure is controversial.

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Background: Systemic lupus erythematosus (SLE) significantly affects the lungs and heart, and pulmonary hypertension (PH) is a severe manifestation that leads to considerable morbidity and mortality.

Objectives: We aimed to determine the prevalence and risk factors of probable SLE-PH, assess the main echocardiographic predictors and develop a potential screening strategy.

Methods: A prospective single-centre study was conducted on 201 patients with SLE who underwent transthoracic echocardiography.

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Article Synopsis
  • Third generation drug-eluting stents (DES), specifically Xlimus, were evaluated in the XLIMIT trial to compare their performance in endothelialization and tissue healing to the Synergy DES.
  • The trial involved 177 patients, assessing primary endpoints of in-stent neointimal volume and percent volume obstruction after 6-9 months using optical coherence tomography (OCT).
  • Results indicated that Xlimus met the non-inferiority criteria compared to Synergy for both primary endpoints, showing similar biological interactions and reassuring OCT outcomes.
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  • Clinical events can occur after percutaneous coronary intervention (PCI), especially in complex cases, and using advanced intracoronary imaging and pressure guidewires may help reduce these risks.
  • The OPTI-XIENCE study is an international, multicenter prospective observational study involving 1,064 patients with specific high-risk characteristics undergoing stent implantation, monitoring them for 12 months.
  • The study aims to evaluate the effectiveness of using these intracoronary tools, with the primary focus on the rate of target lesion failure after one year, while also assessing additional cardiovascular outcomes.
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In the 20th century, research focused on cholesterol and lipoproteins as the key mechanism in establishing atherosclerotic cardiovascular disease (ASCVD). Given that some studies demonstrated subclinical atherosclerosis in subjects without conventional cardiovascular risk factors, the elevated low-density lipoprotein (LDL) levels alone cannot account for the entire burden of atherosclerosis. Hence, large-scale clinical trials demonstrated the operation of immune and inflammatory pathways in ASCVD.

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Cardiac computed tomography (CT) scan was performed in a 69-year-old male with atrial fibrillation radiofrequency ablation who was admitted for transcatheter angioplasty of left inferior pulmonary vein (LIPV) stenosis due to recurrent hemoptysis. CT showed complete ostial occlusion in the area of the LIPV. Occlusion of the pulmonary vein ostium is a rare complication.

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There has been suggestion that vitamin D may play a role in protection against severe infection with COVID-19, defined as the need of intensive care unit admission. In this article a potential mechanism involving angiotensin-converting enzyme 2 (ACE2) is proposed.

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  • Spontaneous coronary artery dissection (SCAD) is a rare cause of acute coronary syndrome, with patients presenting reduced left ventricular ejection fraction (LVEF) displaying different clinical features and outcomes compared to those with preserved LVEF.
  • In a study of 389 patients, those with reduced LVEF (15% of participants) more often experienced severe presentations like ST-segment elevation myocardial infarction (STEMI) and had more extensive coronary artery involvement.
  • Despite receiving specific medications, patients with reduced LVEF had significantly higher mortality rates (9% vs. 0.7%) and readmission for heart failure (4% vs. 0.3%) during a median follow-up of
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