Highly parallel simulation tool for the design of isotachophoresis experiments.

Background: Isotachophoresis (ITP) is a well-established electrokinetic method for separation and preconcentration of analytes. Several simulation tools for ITP have been published, but their use for experimental design is limited by the computational time for a single run and/or by the number of conditions that can be investigated per simulation run. A large fraction of the existing solvers also do not account for ionic strength effects, which can influence whether an analyte focuses in ITP.

CEP signaling coordinates plant immunity with nitrogen status.

Plant endogenous signaling peptides shape growth, development and adaptations to biotic and abiotic stress. Here, we identify C-TERMINALLY ENCODED PEPTIDEs (CEPs) as immune-modulatory phytocytokines in Arabidopsis thaliana. Our data reveals that CEPs induce immune outputs and are required to mount resistance against the leaf-infecting bacterial pathogen Pseudomonas syringae pv.

The role of schedules of reinforcement in the experimental analysis of social behavior.

In this paper, we review some results produced by our research group regarding the role of schedules of reinforcement in social behavior. We discuss data from studies in which we attempted to create conditions in which interdependent gains overlapped with individual reinforcement schedules so that these situations were more or less competitive and conflicting. We argue that normative rules about reinforcement schedules and interdependent reinforcement are crucial for analyzing social behavior since these rules allow us to differentiate the effects of individual and social contingencies or an interaction of both.

Multiple Stakeholder Perspectives of Implementing Work-Related Cognitive Behavioral Therapy (WCBT) in Vocational Service Settings: A Qualitative Exploration of Intervention Acceptability and Sustainability.

Growing mental health treatment access disparities elevate the urgency for identifying and implementing innovative approaches for delivering evidence-supported interventions. Work-related cognitive behavioral therapy (WCBT), a technology-assisted CBT (t-CBT) designed to address social anxiety and employment outcomes among job seekers at vocational service centers and for delivery by vocational service professionals, offers a promising way to increase access to needed mental health care. This qualitative study, guided by the Organizational Transformation Model (OTM), explored factors related to WCBT's implementation at two Jewish Vocational Services (JVS) Human Service sites in Detroit, MI and Los Angeles County, CA.

Patient Language Does Not Impact Need for Manipulation Following Total Knee Arthroplasty.

Socioeconomic factors have been associated with an increased need for manipulation under anesthesia (MUA) following total knee arthroplasty (TKA). The purpose of this study was to compare the rate of MUA and range of motion (ROM) following primary TKA in English and non-English-speaking patients. The authors conducted a retrospective cohort study of all primary TKAs performed at their institution between 2010 and 2017.

Environmental effects on abundance and size of harvested bivalve populations in intertidal shellfish grounds.

Clams, razor clams and cockle are intertidal bivalve species collected on foot in the shellfish grounds of the Rías Altas (NW Spain). Spatio-temporal distribution of these bivalves are typically at the expenses of the environmental conditions of the region; however, the responses to the abiotic conditions are poorly understood. Using data from 6 species (Ruditapes decussatus, Venerupis corrugata, Ruditapes philippinarum, Cerastoderam edule, Donax trunculus and Solen marginatus) sampled in 51 intertidal shellfish grounds during 2007 and 2008, we characterized the influence of the environment (temperature, salinity, nutrient salts, suspended organic matter, or sediment granulometry and composition) on the distribution and size of these species through a comparative statistical analysis.

Decision regret and long-term success rates after ventral buccal mucosa graft urethroplasty.

Objectives: To characterise the long-term success rate of ventral onlay buccal mucosa graft urethroplasty (vBMG) in the management of bulbar urethral stricture disease (USD), assess patient-reported postoperative satisfaction and decision regret, and delineate clinical factors impacting patient-reported metrics.

Subjects And Methods: Patients with prior vBMG for bulbar USD, performed at Cleveland Clinic between 2003 and 2022, were contacted and brief structured interviews were performed. Stricture recurrence and need for secondary procedures, baseline demographics, and patient-reported outcome surveys were collected.

Designed for Satisfaction: The Impact of Single-Family Room Neonatal Intensive Care Units on Family Presence and Satisfaction.

Purpose: This study aimed to assess the extent to which single-family room (SFR) designs enhance family presence and satisfaction and to examine the impact of built environment factors such as proximity, access, privacy, technology, lighting, and acoustics on these outcomes.

Background: The SFR neonatal intensive care unit (NICU) presents a highly intricate setting with distinctive design attributes. This study investigated a NICU environment moving from an open-bay model to a single-family unit.

The sexually dimorphic expression of glutamate transporters and their implication in pain after spinal cord injury.

JOURNAL/nrgr/04.03/01300535-202511000-00033/figure1/v/2024-12-20T164640Z/r/image-tiff In addition to the loss of motor function, ~ 60% of patients develop pain after spinal cord injury. The cellular-molecular mechanisms are not well understood, but the data suggests that plasticity within the rostral, epicenter, and caudal penumbra of the injury site initiates a cellular-molecular interplay that acts as a rewiring mechanism leading to central neuropathic pain.

The Difficult Airway in Patients with Cancer.

Purpose Of Review: The goal of this review is to provide an overview of difficult airway management in the cancer population.

Recent Findings: Difficult airways can be unanticipated; however, several anatomical and physiological features may predict difficult airway management, with several specific for the cancer patient population. New technologies and techniques for airway management, including non-invasive oxygenation, and even the utilization of ECMO, have led to better outcomes and decreased morbidity.

Perivascular phosphorylated TDP-43 inclusions are associated with Alzheimer's disease pathology and loss of CD146 and Aquaporin-4.

The majority of patients with Alzheimer's disease (AD) exhibit aggregates of Trans-active response DNA binding protein 43 (TDP-43) in their hippocampus, which is associated with a more aggressive disease progression. The TDP-43 inclusions are commonly found in neurons, but also in astrocytes. The impact of the inclusions in astrocytes is less known.

Floral resource availability declines and florivory increases along an elevation gradient in a highly biodiverse community.

Background And Aims: Flower-visitor interactions comprise a continuum of behaviors, from mutualistic partners to antagonistic visitors. Despite being relatively frequent in natural communities, florivory remains unexplored, especially when comprising abiotic factors, spatio-temporal variations and global environmental changes. Here, we addressed the variation of florivory driven by changes in elevation and temporal flower availability.

Initial clinical evidence on biperiden as antiepileptogenic after traumatic brain injury-a randomized clinical trial.

There is currently no efficacious intervention for preventing post-traumatic epilepsy (PTE). Preclinical studies support the potential use of anticholinergics for this condition. The purpose of this study was to evaluate the effects of biperiden as an intervention for preventing PTE.

Venous Anomalies in Overgrowth Syndromes.

Overgrowth syndromes, particularly within the PIK3CA-related overgrowth syndrome (PROS) spectrum, are commonly associated with venous anomalies. The anomalies include spongiform venous malformations and persistent embryonic veins, such as the lateral marginal vein (of Servelle). The anomalous veins pose a significant risk of thromboembolic disease and should be occluded, preferably earlier in life.

Sex, tissue, and mitochondrial interactions modify the transcriptional response to rapamycin in Drosophila.

Background: Many common diseases exhibit uncontrolled mTOR signaling, prompting considerable interest in the therapeutic potential of mTOR inhibitors, such as rapamycin, to treat a range of conditions, including cancer, aging-related pathologies, and neurological disorders. Despite encouraging preclinical results, the success of mTOR interventions in the clinic has been limited by off-target side effects and dose-limiting toxicities. Improving clinical efficacy and mitigating side effects require a better understanding of the influence of key clinical factors, such as sex, tissue, and genomic background, on the outcomes of mTOR-targeting therapies.

Computing tools for effective field theories: SMEFT-Tools 2022 Workshop Report, 14-16th September 2022, Zürich.

In recent years, theoretical and phenomenological studies with effective field theories have become a trending and prolific line of research in the field of high-energy physics. In order to discuss present and future prospects concerning automated tools in this field, the SMEFT-Tools 2022 workshop was held at the University of Zurich from 14th-16th September 2022. The current document collects and summarizes the content of this workshop.

Spermidine Synthase Localization in Retinal Layers: Early Age Changes.

Polyamine (PA) spermidine (SPD) plays a crucial role in aging. Since SPD accumulates in glial cells, particularly in Müller retinal cells (MCs), the expression of the SPD-synthesizing enzyme spermidine synthase (SpdS) in Müller glia and age-dependent SpdS activity are not known. We used immunocytochemistry, Western blot (WB), and image analysis on rat retinae at postnatal days 3, 21, and 120.