Publications by authors named "Santiago Alfayate Miguelez"
Article Synopsis
- This study evaluates nirsevimab, a monoclonal antibody, for preventing respiratory syncytial virus (RSV) infections in infants under ten months in Spain.
- It involved a large immunization campaign where infants born after April 1, 2023, received nirsevimab either at birth or through a catch-up program.
- Results showed nirsevimab had an overall effectiveness of 75.8% and 80.2% in the catch-up group, highlighting its role in reducing RSV-related illnesses in primary care settings.
A multifaceted, participatory, open program based on a qualitative and quantitative approach was developed in the Region of Murcia (Spain) aimed to reduce antibiotic use in children under 3 years of age diagnosed with upper respiratory tract infections (acute otitis media, pharyngitis, and common cold). Antibiotic consumption was measured using the defined daily dose per 1000 inhabitants per day (DHD). Pre-intervention data showed a prevalence of antibiotic prescriptions in the primary care setting of 45.
View Article and Find Full Text PDFEarly estimates of nirsevimab immunoprophylaxis effectiveness against hospital admission for respiratory syncytial virus lower respiratory tract infections in infants, Spain, October 2023 to January 2024.
Euro Surveill
February 2024
Article Synopsis
- * This effectiveness was validated through two different research methods (screening and test-negative) in a multicenter study across nine hospitals in three regions.
- * The antibody did not provide any protection against hospitalizations for lower respiratory tract infections caused by viruses other than RSV, and these findings could help influence public health policies.
Rotavirus (RV) is the most common cause of severe gastroenteritis (GE) in infants and young children worldwide and is associated with a significant clinical and economic burden. The objective of this study was to analyze the characteristics, healthcare resource utilization and the direct medical costs related to RVGE hospitalizations in Spain. An observational, multicenter, cross-sectional study was conducted from June 2013 to May 2018 at the pediatric departments of 12 hospitals from different Spanish regions.
View Article and Find Full Text PDFBackground: An epidemiological study of Streptococcus pneumoniae nasopharyngeal carriage in healthy children was carried out five years after the introduction of the 13-valent pneumococcal conjugate vaccine (PCV13).
Objectives: Study the impact of pediatric vaccination with PCV13, and other associated epidemiological factors on the status of nasopharyngeal carriage, the circulating pneumococcal serotypes, and the antibiotic susceptibility to more frequently used antibiotics.
Methods: A multi-center study was carried out in Primary Health Care, which included 1821 healthy children aged 1 to 4 years old.
Rational use of antimicrobials in the treatment of upper airway infections.
J Pediatr (Rio J)
January 2021
Objective: To analyze the main cause of the irresponsible use of antibiotics at the pediatric level in a very frequent, usually self-limited, and typically viral condition: upper airway respiratory infections.
Sources: Different databases were searched using specific terms related to resistance to antibiotics, upper airway respiratory infections, and pediatrics patients.
Summary Of The Findings: Effectiveness varies depending on the place, the form of intervention, and the resources used.
Background: Haemophilus influenzae, a colonizer of the nasopharynx, in children causes mainly otitis and sinusitis. The primary objective of this study was to determine the prevalence of pharyngeal colonization by H. influenzae, and the secondary objectives were to identify risk factors associated with H.
View Article and Find Full Text PDFUnlabelled: The aim of the present study is to clarify the association between environmental exposures and non-tuberculous mycobacterial (NTM) lymphadenitis, during the last decade, in a population of children. In children up to 14 years of age in a pediatric tertiary hospital, all cases of NTM lymphadenopathy with a specific microbiological diagnosis, from January 2004 to January 2015, were reviewed. This is a case-control study (1:5 proportion), in which the prevalence of environmental factors between cases and controls was compared by means of a multivariate logistic regression analysis.
View Article and Find Full Text PDFBackground And Objectives: Streptococcus pneumoniae is a human pathogen that requires prior nasopharyngeal colonization to cause disease. An epidemiological study was conducted on nasopharyngeal carriers of pneumococci in healthy children in Murcia after the introduction of the VCN7, and immediately before the marketing of new vaccines, with the aim of determining the influence of vaccination in our geographic area, and other factors in relation to the state of being a carrier, and the different circulating serotypes.
Methods: A multicentre study was conducted in in 60 primary care health centres in summer 2009 and winter of 2010.
Enterovirus reverse transcriptase polymerase chain reaction assay in cerebrospinal fluid: an essential tool in meningitis management in childhood.
Enferm Infecc Microbiol Clin
February 2013
Article Synopsis
- Enteroviruses (EV) are a primary cause of aseptic meningitis in children, making quick diagnosis crucial to eliminate other possibilities; the RT-PCR test in cerebrospinal fluid (CSF) is an efficient diagnostic tool.
- The study analyzed data from 92 children (average age 2.5 years) with positive EV RT-PCR results, finding that many had no pleocytosis in their CSF, leading to shorter hospital stays and quick discharges.
- The RT-PCR assay significantly improved patient management by allowing faster diagnosis, reducing unnecessary antibiotic use, and should be included in the initial assessment of children with aseptic meningitis, especially during peak times.