Publications by authors named "Santiago Abengoechea"
Article Synopsis
- This study evaluated the effectiveness of a biosimilar drug, QL1205, compared to the established drug ranibizumab (Lucentis®) in patients with neovascular age-related macular degeneration (nAMD) through a rigorous phase 3 trial.* -
- A total of 616 treatment-naïve patients were randomly assigned to receive either QL1205 or ranibizumab, and both groups were given injections every four weeks for 48 weeks, with the main focus on changes in best-corrected visual acuity (BCVA).* -
- Results showed similar improvements in visual acuity for both QL1205 (+6.3 letters) and ranibizumab (+7.
Objective: To evaluate the efficacy of photodynamic therapy (PDT) for symptomatic circumscribed choroidal hemangioma (CCH).
Design: A retrospective case series analysis through chart review of patients with CCH treated by means of PDT.
Participants: Thirteen patients with circumscribed choroidal hemangioma.
Objective: To simultaneously evaluate tyrosine nitrosylation and phosphorylation levels of vitreous interleukins of patients with diabetic retinopathy, in which abnormal tyrosine phosphorylation has been previously described.
Research Design And Methods: Specific immunoprecipitation of interleukins IL-1α, IL-1β, IL-2 and IL-7 was carried out in samples obtained during vitrectomy performed for proliferative diabetic retinopathy in patients (n=12) and for macular hole in controls (n=12). Tyrosine nitrosylation and phosphorylation levels of the immunoprecipitated interleukins were analysed by Western blot with the respective specific antibodies and correlated.
Purpose: To evaluate the degree of phosphorylation of vitreous proteins in patients with type 2 diabetes mellitus and diabetic retinopathy compared with a group of control subjects without diabetes and of similar age and sex.
Methods: In samples obtained after vitrectomy for diabetic retinopathy in patients and for macular hole in control subjects, immunoblot techniques were applied to a mini-array system for quantification of a wide range of chemokines and vasoactive peptides and proteins. Antiphosphotyrosine antibody was used for tyrosine phosphorylation evaluation and results were expressed as the percentage of variation compared with that in control subjects.