Arjunolic acid, a pentacyclic triterpenoidal saponin of Terminalia arjuna bark protects neurons from oxidative stress associated damage in focal cerebral ischemia and reperfusion.

Background: Arjunolic acid (AA), a pentacyclic triterpenoidal saponin of Terminalia arjuna is well recognized for its antioxidant properties. We proposed to evaluate its antioxidant potential against focal cerebral ischemia reperfusion (I/R) injury in rats subjected to middle cerebral artery occlusion (MCAO).

Methods: In the present study, rats were randomly divided into a sham, MCAO, AA (10 and 20mg/kg) treated groups.

Punicalagin attenuated cerebral ischemia-reperfusion insult via inhibition of proinflammatory cytokines, up-regulation of Bcl-2, down-regulation of Bax, and caspase-3.

Punicalagin (PG) is a hydrolysable tannin compound found in Punica granatum L. The purpose of the present work is to explore the neuroprotective mechanism of PG against ischemia-reperfusion (I/R) injury in rat model of middle cerebral artery occlusion (MCAO). Rats were randomly divided into sham, MCAO, and PG-treated groups.