Publications by authors named "Santhoshkumar Muthu"

Article Synopsis
  • The study focuses on identifying new covalent inhibitors of Keap1 that can activate Nrf2 by modifying key cysteine residues (C151, C273, C288) to enhance neuroprotection.
  • Researchers used various computational and in-vitro methods, concluding that plumbagin formed stable covalent bonds with the cysteine residues and demonstrated neuroprotective properties in cell studies.
  • Plumbagin not only improved cognitive function and reduced symptoms in rat models of Parkinson's disease but also activated Nrf2, suggesting it has potential antioxidant and anti-inflammatory effects.
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Phytoestrogens are dietary estrogens having similar structure as of estrogen. Some of these phytoestrogens are androgen receptor (AR) antagonists and exhibit preventive role in the prostate cancer. However, in androgen-independent prostate cancer (AIPC) the ARs were mutated (T877A, W741L, F876L, etc.

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