Antibacterial Activity of (Rosella) Using Methanolic Extract.

L. (Rosella) has a long history of use in food preparation, herbal remedies, hot and cold beverages, food industry flavoring, and herbal drinks. More than 300 species of are grown all over the world.

Antimicrobial Activity and Biological Compatibility Study of Methanolic Crude Extract of (Flower).

is a little flowering tree or shrub that is indigenous to India and Sri Lanka. It is also known by the names Tanner's Cassia and Avarampoo. It is a member of the Fabaceae family and is popular for its therapeutic and beautifying effects.

Antimicrobial Activity of Crude Metabolites of using Methanol Extract against the Clinical Pathogens.

Background: The , also known as grapevine, is one of the most widely grown fruit crops in the world and is renowned for producing wine and grapes. Other than their importance in gastronomy and ecology, certain sections of the plant have shown promising bioactive qualities. The numerous phytochemicals in this plant, including flavonoids, stilbenes, and phenolic acids, are what gives its antibacterial and antifungal properties though the antimicrobial properties of seed extract have to be studied, however in this present study we focus on screening and its biological compatibility of seed extracts of .

An Indian butyrylcholinesterase variant L307P is not structurally stable: a molecular dynamics simulation study.

The human butyrylcholinesterase (BChE) activity is less than 1% in the serum of silent variant individuals of Vysya community in India. They are homozygous for a point mutation at codon 307 (CTT → CCT) resulting in the substitution of leucine 307 by proline. The reason for the disappearance of the protein in the serum has not been explicated till date.

Footprinting of inhibitor interactions of in silico identified inhibitors of trypanothione reductase of Leishmania parasite.

Structure-based virtual screening of NCI Diversity set II compounds was performed to indentify novel inhibitor scaffolds of trypanothione reductase (TR) from Leishmania infantum. The top 50 ranked hits were clustered using the AuPoSOM tool. Majority of the top-ranked compounds were Tricyclic.

Screening natural products database for identification of potential antileishmanial chemotherapeutic agents.

Leishmaniasis is a parasitic infection caused by unicellular protozoan organism belonging to the family Trypanosomatidae. Among various forms of the disease, visceral leishmaniasis is the most lethal and caused by Leishmania infantum or Leishmania donovani. The redox metabolism of parasite requires a key enzyme, trypanothione reductase which is a validated drug target.

Mitogen-activated protein kinase 4 of Leishmania parasite as a therapeutic target.

Protein kinases are important regulators of many different cellular processes such as transcriptional control, cell cycle progression and differentiation, and have drawn much attention as potential drug targets. Leishmania mexicana mitogen-activated protein kinase 4 (LmxMPK4) is crucial for the survival of the parasite. As the crystal structure of the enzyme is not known, we have used bioinformatics techniques to model LmxMPK4 structure.

Molecular docking studies of selected tricyclic and quinone derivatives on trypanothione reductase of Leishmania infantum.

Visceral leishmaniasis, most lethal form of Leishmaniasis, is caused by Leishmania infantum in the Old world. Current therapeutics for the disease is associated with a risk of high toxicity and development of drug resistant strains. Thiol-redox metabolism involving trypanothione and trypanothione reductase, key for survival of Leishmania, is a validated target for rational drug design.