Publications by authors named "Santana L"

Background: Providing excellent care to patients with acute burns can result in lower mortality and disability in the long-term. There are no specific instruments to evaluate the quality of care provided at this stage of treatment. This study aims to create an instrument to evaluate the quality of hospital care provided to patients with acute burns in Brazil.

View Article and Find Full Text PDF

Introduction:  Erector spinae plane (ESP) blocks, thoracic epidural, and patient-controlled analgesia (PCA) have all been used for perioperative pain management in the Nuss procedure without a consensus on what modality produces the best outcomes. Intercostal nerve cryoablation (INC) is a relatively new modality that involves freezing the nerves to prevent pain during recovery. Our hypothesis is that using INC for the Nuss procedure will decrease opioid use, pain scores, and length of stay (LOS) but will increase cost compared with ESP block, thoracic epidural, and PCA.

View Article and Find Full Text PDF

Objective: Germline and somatic drivers are identified in 30% and 40% of pheochromocytomas and paragangliomas (PPGLs), respectively. In this study, we investigated the genetic landscape of PPGLs in a Brazilian cohort.

Methods: We studied 182 index patients with PPGLs (116 females and 66 males), comprising 118 pheochromocytoma and 70 paraganglioma cases.

View Article and Find Full Text PDF

The use of industrial residues in civil construction is an exciting alternative to mitigate environmental impacts and promote the circular economy. This work developed new compositions of geopolymer mortars activated by NaOH from fine kaolin residue (RCF), coarse kaolin residue (RCG) and granite (RG). All residues were benefited and characterized by chemical analysis (X-ray fluorescence), mineralogical phases (X-ray diffraction) and granulometry (laser granulometry).

View Article and Find Full Text PDF

Morus nigra L., commonly known as black mulberry, is a significant plant species in the pharmaceutical and cosmetic industries. It is also considered an Unconventional Food Plant with potential applications in nutrition.

View Article and Find Full Text PDF

Objective: to identify the prevalence of mental and behavioral disorders among nursing workers in the context of COVID-19 and its associated factors.

Method: cross-sectional web survey carried out between October 2021 and January 2022, with 1.073 nursing professionals.

View Article and Find Full Text PDF

Artificial intelligence (AI) has been studied and applied to medicines and vaccine development. However, there is still a need to understand the processes used and improve them. With this letter, we draw attention to AI use as a tool in vaccine production, supporting scientists and enabling optimization in this process.

View Article and Find Full Text PDF

Native starches have a high potential for producing capsules by electrospraying despite still being little explored as biopolymeric material. Thus, the present study aimed to investigate the electrospraying capacity of native starches from different sources (cassava, corn, wheat, and sweet potato). The concentration of starch in the polymer solutions was varied from 3 % to 10 % (w/v) to investigate the impact of both starch source and concentration on the electrospraying process.

View Article and Find Full Text PDF

Immunization is a challenge for the elderly population and can leave this group more vulnerable to opportunistic pathogens such as SARS-CoV-2. Due to this situation, while vaccines were in the development phase, hypotheses were raised about the role of vitamins and minerals in immunization. In Brazil, there was a controversy regarding the well-known COVID-19 Kit, a standardized prescription for positive cases that contained zinc, and vitamin D, and anti-parasitic drugs.

View Article and Find Full Text PDF
Article Synopsis
  • A 32-year-old woman with a history of anorexia nervosa experienced worsening bingeing and purging behaviors, leading to an evaluation that revealed a body mass index near the underweight range and indicative symptoms of bulimia nervosa (BN).
  • Despite no other psychiatric conditions like mood or anxiety disorders, she struggled with focus, time management, and completing tasks, affecting her personal and professional life.
  • Treatment with fluoxetine and cognitive behavioral therapy did not help, but starting lisdexamfetamine significantly reduced her bingeing and purging behaviors while improving her concentration, suggesting a potential link between ADHD and bulimia nervosa in high-functioning adult women.
View Article and Find Full Text PDF

Objective: To assess the implementation of the bedside medication preparation process in an Intensive Care Unit, following a quality improvement cycle.

Method: A quasi-experimental study with non-paired samples, pre- and post-implementation, conducted in an Intensive Care Unit of a public hospital in southern Brazil, from September 2022 to April 2023, following the guidelines of the Standards for Quality Improvement Reporting Excellence 2.0.

View Article and Find Full Text PDF

Background: Increased vascular Ca1.2 channel function causes enhanced arterial tone during hypertension. This is mediated by elevations in angiotensin II/protein kinase C signaling.

View Article and Find Full Text PDF

Cellulose possesses numerous advantageous properties and is a precursor to compounds and derivatives. The objective of this study was to isolate and characterize cellulose from Butia fruits and simultaneously produce cellulose nanofibers and cellulose acetate from the isolated cellulose. Cellulose extraction was performed using a combination of alkaline and bleaching treatments, while the production of cellulose nanofibers and cellulose acetate was achieved through acid hydrolysis and acetylation, respectively.

View Article and Find Full Text PDF

: Jump test assessment is commonly used for physical tests, with different type of devices used for its evaluation. The purpose of the present study was to examine the validity and reliability of a freely accessible mobile application (VertVision, version 2.0.

View Article and Find Full Text PDF
Article Synopsis
  • Muscle-specific kinase (MuSK) is crucial for creating and maintaining neuromuscular synapses, and its activation can help treat diseases affecting these connections, such as congenital myasthenia (CM).
  • ARGX-119 is a novel humanized monoclonal antibody designed to specifically activate MuSK, improving neuromuscular junction function without disrupting the natural ligand, neural Agrin.
  • In studies, ARGX-119 successfully improved neuromuscular function in mouse models of CM, showing promise for treating related neuromuscular disorders in humans, justifying its further clinical development.
View Article and Find Full Text PDF

Background: Aldosterone excess chronically induces oxidative stress and cell proliferation. Previously, a single study investigated primary aldosteronism (PA) in patients with papillary thyroid cancer (PTC), albeit without a matched control group.

Methods: We conducted a propensity score matched case-control study to investigate the association between PA and PTC in individuals with arterial hypertension (HT).

View Article and Find Full Text PDF
Article Synopsis
  • Myasthenia gravis (MG) is a severe illness that causes muscle weakness because signals from nerves to muscles don't work well.
  • In some types of MG, the body's immune system mistakenly attacks important proteins that help muscles respond to signals.
  • Researchers found that special antibodies from MG patients can cause muscle disease in mice, but a new type of antibody can help treat it without shutting down the whole immune system.
View Article and Find Full Text PDF
Article Synopsis
  • Plant growth-promoting bacteria (PGPB) can enhance crop yield and nutrition, with this study focusing on their effects on dwarf castor beans following legumes and grasses in Brazil.
  • The research tested various nitrogen (N) application rates alongside PGPB inoculation, finding significant increases in grain and oil yields at specific N rates, especially with inoculation treatments.
  • The findings suggest that combining optimal N rates with PGPB inoculation can lead to higher castor bean yields while reducing fertilizer use, promoting more sustainable agricultural practices.
View Article and Find Full Text PDF
Article Synopsis
  • This study assessed the effects of ethanolic and aqueous extracts from a plant's bark on mice fed a high-fat diet and analyzed the extracts' chemical composition.
  • The results indicated that while the aqueous extract had better antioxidant properties, neither extract significantly affected weight gain or fat accumulation, but they did decrease food intake.
  • Additionally, the extracts increased leptin levels, which might promote feelings of fullness, but negatively impacted other inflammatory and hormonal markers, showing no effective treatment for diet-related metabolic issues.
View Article and Find Full Text PDF