The Association Between Major Depression and Alzheimer's Disease Risk: Evidence from a 12-Year Longitudinal Study.

The relationship between depression, particularly major depression (MD), as a risk factor for Alzheimer's disease (AD) is well established; however, its precise role remains contested. Findings from the fourth wave of the ZARADEMP longitudinal study provide further insights into the association between MD and AD risk. : This study aimed to examine the association between MD and incident AD, controlling for established risk factors.

Conceptualization of Depression among Medical Students and Its Differences during Medical Education.

The definition of mental disorders has been traditionally a matter of discussion, and it has relevant implications in research and healthcare. Our aim was to explore the conceptualization medical students have of depression and to determine differences across academic years. The Maudsley Attitudes Questionnaire was adapted through a double translation, double back-translation and a preliminary validation, obtaining a Spanish edition.

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Introduction: The LIfestyle for BRAin Health (LIBRA) index yields a dementia risk score based on modifiable lifestyle factors and is validated in Western samples. We investigated whether the association between LIBRA scores and incident dementia is moderated by geographical location or sociodemographic characteristics.

Methods: We combined data from 21 prospective cohorts across six continents (N = 31,680) and conducted cohort-specific Cox proportional hazard regression analyses in a two-step individual participant data meta-analysis.

Breast Cancer Diagnosis Using Texture and Shape Features in MRI.

Contrast-enhanced magnetic resonance (MR) breast imaging represents a tool with great potential for the detection, evaluation and diagnosis of breast cancer (BC). Due to its high sensitivity and in combination with medical imaging biomarkers, it can overcome setbacks and limitations manifested in other diagnostic modalities such as mammography or ultrasound. In order to aid and assist clinicians in the diagnosis of BC, a methodology based on the extraction of 2D texture and 3D shape features in MR images is proposed.

Deep Learning Segmentation of Lower Extremities Radiographs for an Automatic Leg Length Discrepancy Measurement.

Leg length measurement is relevant for the early diagnostic and treatment of discrepancies as they are related with orthopedic and biomechanical changes. Simple radiology constitutes the gold standard on which radiologists perform manual lower limb measurements. It is a simple task but represents an inefficient use of their time, expertise and knowledge that could be spent in more complex labors.

Prevalence of gastrointestinal symptoms in autism spectrum disorder: A meta-analysis.

Introduction: A high prevalence of gastrointestinal (GI) symptoms has been described in children and adolescents with autism spectrum disorder (ASD). In addition, there is evidence that presence of GI symptoms is associated to greater severity of ASD. However, the frequency of GI symptoms in children and adolescents with ASD varies widely across studies, and their true prevalence is unknown.

Prevalence of Burnout among Teachers during the COVID-19 Pandemic: A Meta-Analysis.

Since the start of the COVID-19 pandemic, many studies have found that there has been a lot of teacher overload. One of the additional burdens has been that they have had to teach online. In addition, when they returned to face-to-face classes, they had to follow all the hygiene rules so that the COVID-19 virus would not spread.

PTSD (Posttraumatic Stress Disorder) in Teachers: A Mini Meta-Analysis during COVID-19.

Background: Since March 2020, when the World Health Organization (WHO) declared the COVID-19 pandemic, in order to stop the spread of the virus, unprecedented measures were taken worldwide. One of the most important measures was the closure of schools and educational centers around the world in 2020, and very extreme health protocols have been in place in educational centers since they were reopened. From early childhood education to universities, teachers first had to adapt in a short period time to online classes and then continuously readapt to new protocols according to the pandemic situation.

Clinically significant anxiety as a risk factor for Alzheimer's disease: Results from a 10-year follow-up community study.

Objective: There is growing evidence for an association between anxiety and an increased risk of dementia, but it is not clear whether anxiety is a risk factor or a prodromic symptom. In this study, we investigated if clinically significant anxiety increases the risk of developing Alzheimer's disease (AD) up to 10 years later.

Methods: We used data from the longitudinal Zaragoza Dementia and Depression (ZARADEMP) Project.

The effect of occupation on the incidence of vascular dementia: A 12-year follow-up cohort study.

Introduction: Vascular dementia (DV) is the second cause of dementia with 15.8-20% of cases. Previous studies of the effect of occupation in DV do not show conclusive results, therefore, the objective was to analyze if the type of occupation can vary the risk of developing DV in those older than 55 years.

The emotional state of young people in northern Spain after one year and a half of the COVID-19 pandemic.

Background And Objectives: Since the beginning of the COVID-19 pandemic, the young population has been suffering from an accumulation of psychological symptoms in northern Spain. The main objectives of this study were (1) to assess whether psychological symptoms persisted after one year and a half of the COVID-19 pandemic in northern Spain sample of young people, and (2) to analyze whether pandemic-specific variables (having a chronic illness, living with a person who has a chronic illness, having been infected with COVID-19, having a close person who has died or believing that people are respecting the measures imposed) are related to psychological symptomatology.

Methods: Symptoms of stress, anxiety, and depression were measured using the Depression and Stress Anxiety Scale-21 (DASS-21).

Texture Analysis in MRI of the Knee for an Early Diagnosis of Osteoarthritis.

Osteoarthritis is one of the most disabling diseases in developed countries. Its etiology is not firmly established, and the diagnosis is made by observing radiographs, assigning a degree of severity based on the information displayed. For this reason, the diagnosis is usually late and determined by the subjectivity of the doctor, which implies a restriction of the treatment.

Multiclass Classification of Prostate Tumors Following an MR Image Analysis-Based Radiomics Approach.

Prostate cancer is one of the most common cancers in men, with symptoms that may be confused with those caused by benign prostatic hyperplasia. One of the key aspects of treating prostate cancer is its early detection, increasing life expectancy and improving the quality of life of those patients. However, the tests performed are often invasive, resulting in a biopsy.

Emotional State of Mexican University Students in the COVID-19 Pandemic.

Background: Since the WHO declared the COVID-19 crisis a pandemic in March 2020, the young population is suffering from a range of psychological symptoms. The present study measured symptoms of stress, anxiety and depression in university students of Saltillo, Mexico, using the Depression and Anxiety Stress Scale-21 (DASS-21).

Methods: The DASS-21 scale and an ad hoc questionnaire were used to collect sociodemographic information.

Automatic Multi-Atlas Liver Segmentation and Couinaud Classification from CT Volumes.

Primary Live Cancer (PLC) is the sixth most common cancer worldwide and its occurrence predominates in patients with chronic liver diseases and other risk factors like hepatitis B and C. Treatment of PLC and malignant liver tumors depend both in tumor characteristics and the functional status of the organ, thus must be individualized for each patient. Liver segmentation and classification according to Couinaud's classification is essential for computer-aided diagnosis and treatment planning, however, manual segmentation of the liver volume slice by slice can be a time-consuming and challenging task and it is highly dependent on the experience of the user.

Meta-Analysis of Prevalence of Depression in Dental Students during COVID-19 Pandemic.

: The COVID-19 pandemic has a negative impact on the mental health of the population in general, and in college students in particular. Dental students have seen their teaching altered and their clinical practice reduced. This study was aimed at conducting a systematic review and meta-analysis of studies reporting levels of depression among dental students during the COVID-19 and estimating the pooled prevalence of depression.

Education, Occupational Complexity, and Incident Dementia: A COSMIC Collaborative Cohort Study.

Background: Education and occupational complexity are main sources of mental engagement during early life and adulthood respectively, but research findings are not conclusive regarding protective effects of these factors against late-life dementia.

Objective: This project aimed to examine the unique contributions of education and occupational complexity to incident dementia, and to assess the mediating effects of occupational complexity on the association between education and dementia across diverse cohorts.

Method: We used data from 10,195 participants (median baseline age = 74.

Prevalence of Anxiety in Dental Students during the COVID-19 Outbreak: A Meta-Analysis.

Background: Since the onset of the COVID-19 pandemic, the psychological state of university students has been a cause for concern. In particular, odontology students have experienced symptoms of anxiety due to the closure of universities and the suspension of clinical training.

Methods: Medline via PubMed was searched for studies on the prevalence of anxiety in dental undergraduates, published from 1 December 2019 to 1 August 2021.

Prevalence of Anxiety, Depression, and Stress among Teachers during the COVID-19 Pandemic: A Rapid Systematic Review with Meta-Analysis.

Background: Since the beginning of the COVID-19 pandemic, teachers have been accumulating adverse psychological symptoms due to the closure of educational centers and the need to adapt to different teaching modalities.

Methods: Medline and PubMed were searched for studies on the prevalence of depression, anxiety, stress, and burn-out in teachers, published from 1 December 2019 to 15 June 2021.

Results: In total, eight studies were included in this study.

Determination of Non-Invasive Biomarkers for the Assessment of Fibrosis, Steatosis and Hepatic Iron Overload by MR Image Analysis. A Pilot Study.

The reference diagnostic test of fibrosis, steatosis, and hepatic iron overload is liver biopsy, a clear invasive procedure. The main objective of this work was to propose HSA, or human serum albumin, as a biomarker for the assessment of fibrosis and to study non-invasive biomarkers for the assessment of steatosis and hepatic iron overload by means of an MR image acquisition protocol. It was performed on a set of eight subjects to determine fibrosis, steatosis, and hepatic iron overload with four different MRI sequences.

Impaired metabolic health over-time and high abdominal fat are prospectively associated with high-sensitivity C-reactive protein in children: The IDEFICS study.

Background: Metabolic risk and inflammatory state have an early life onset and are associated with future diseases.

Objectives: To assess the association between metabolic syndrome (MetS) and metabolic health with high-sensitive C-reactive protein (hsCRP), cross-sectionally and longitudinally, in children.

Methods: 2913 European children (2-10 years) from eight countries from the IDEFICS study were investigated.