Long-term outcomes of great saphenous vein harvest techniques for infrainguinal arterial bypass in a Medicare-matched registry database.

Objective: Long-term outcomes for harvesting techniques for great saphenous vein (GSV) and its impact on the outcomes of infrainguinal arterial bypass remains largely unknown. Endoscopic GSV harvesting (EVH) has emerged as a less invasive alternative to conventional open techniques. Using the Vascular Quality initiative Vascular Implant Surveillance & Interventional Outcomes Network (VQI-VISION) database, we compared the long-term outcomes of infrainguinal arterial bypass using open and endoscopic GSV harvest techniques.

Variables affecting complication rates in type III paediatric supracondylar humerus fractures.

Purpose: Unstable supracondylar humerus (SCH) fractures may have different outcomes as a result of direction of displacement and pin configuration. This study evaluates the impact of fracture displacement, pin configuration and fellowship training on clinical and radiographic outcomes in unstable fractures.

Methods: A total of 99 patients with completely displaced type III fractures were identified at an academic centre and a local community hospital.

Fluid Restriction Dehydration Increase Core Temperature During Endurance Exercise Compared to Exercise Induced Dehydration.

This study aimed to evaluate the difference in heart rate and core temperature during aerobic exercise between two forms of dehydration: exercise-induced (EI) and fluid restricted (FR). Twenty-two subjects ( = 22; 83.35 ± 13.

Postweaning Isolation Alters the Responses of Auditory Neurons to Serotonergic Modulation.

Juvenile social experience, such as social isolation, has profound effects on communicative behavior, including signal production and reception. In the current study, we explored responsiveness to the neuromodulator serotonin as a potential mechanistic link between early life social isolation and auditory processing. The serotonergic system is sensitive to social isolation in many brain regions including the inferior colliculus (IC), an auditory midbrain nucleus.

Superior Detection of Faces in Male Infants at 2 Months.

Females generally attend more to social information than males; however, little is known about the early development of these sex differences. With eye tracking, 2-month olds' (N = 101; 44 females) social orienting to faces was measured within four-item image arrays. Infants were more likely to detect human faces compared to objects, suggesting a functional face detection system.

Putting the "Joy" in joint attention: affective-gestural synchrony by parents who point for their babies.

Despite a growing body of work examining the expression of infants' positive emotion in joint attention contexts, few studies have examined the moment-by-moment dynamics of emotional signaling by adults interacting with babies in these contexts. We invited 73 parents of infants (three fathers) to our laboratory, comprising parent-infant dyads with babies at 6 (n = 15), 9 (n = 15), 12 (n = 15), 15 (n = 14), and 18 (n = 14) months of age. Parents were asked to sit in a chair centered on the long axis of a room and to point to distant dolls (2.

The prevalence of and specific risk factors for venous thromboembolic disease following elective spine surgery.

Background: Venous thromboembolic disease, including deep venous thrombosis and pulmonary embolism, is a serious and potentially life-threatening complication following orthopaedic surgical procedures. We sought to investigate the prevalence of thromboembolism as well as the efficacy and complications of various prophylactic measures in a population of patients who had undergone elective spine surgery.

Methods: A meta-analysis and univariate logistic regression were performed on selected studies to determine the prevalence of and risk factors for deep venous thrombosis and pulmonary embolism following elective spine surgery.

A rare case of posterior interosseous nerve palsy associated with radial head fracture.

Background: Radial head fractures are the most common fractures occurring about the elbow in adults, but there have been few reported cases of associated nerve injury. The little-known posterior interosseous nerve travels in close proximity to the radial head and is particularly susceptible to injury.

Objectives: The objectives of this case report include raising awareness of the possibility of posterior interosseous nerve palsy after radial head fracture and reviewing the clinical assessment of the posterior interosseous nerve to exclude occult injury.

The effect of fluoroquinolone antibiotics on growing cartilage in the lamb model.

Background: The fluoroquinolones are a relatively new class of antimicrobials with an appealing spectrum of activity. Their use in pediatric medicine is limited because of the concern over possible growth inhibition, as published reports have documented articular cartilage damage in animal models after their administration. These data, extrapolated to include the epiphyseal cartilage, suggest that these agents may reduce growth rates, but limited human data are at the least equivocal, if not strictly contradictory to such claims.

The effect of periosteal resection on tibial growth velocity measured by microtransducer technology in lambs.

Background: Disruption of the periosteum, whether traumatic or elective, has long been known to accelerate growth in the developing skeleton. However, the extent, timing, and mechanism of the resultant increase in growth velocity (if any) remain undefined. The primary research questions were: Does periosteal resection result in a change (increase) in growth velocity of a long bone at the growth plate? When does the effect start after the resection and for how long? Finally, which of several cellular mechanisms is most likely responsible for the change in growth velocity?

Methods: Five lambs underwent proximal tibial growth plate periosteal resection with subsequent measurement of growth velocity by implantable microtransducers or fluorochrome labeling.

Rapid progression of scoliosis following insertion of intrathecal baclofen pump.

Placement of an intrathecal baclofen pump is a common treatment of spasticity in cerebral palsy patients. Though effective, the hardware is prone to malfunction, and multiple revisions are often necessary. Additional complications have also been described, including infection and drug toxicity or withdrawal.

Endoscopic cerebral aqueductoplasty: a trans-fourth ventricle approach.

Object: Advances in endoscopic technology have afforded the neurosurgeon new avenues in the treatment of hydrocephalus, rendering many patients independent of shunts, thus averting shunt complications and failure. Cerebral aqueductoplasty has gained popularity as an effective treatment for membranous and short-segment stenoses of the sylvian aqueduct. Traditionally, this procedure has been performed via a coronal approach, passing through the lateral ventricle, foramen of Monro, and third ventricle into the aqueduct.

The use of quick-brain magnetic resonance imaging in the evaluation of shunt-treated hydrocephalus.

Object: Children with shunt-treated hydrocephalus are exposed to serious amounts of radiation when undergoing computerized tomography (CT) scanning. The authors report their clinical experience with single-shot fast-spin echo (SSFSE) (quick-brain) magnetic resonance (MR) imaging as the modality of choice for the workup and follow up of patients in whom a shunt has been placed to treat hydrocephalus.

Methods: A retrospective chart review was performed to obtain data on all cases in which a quick-brain MR image was acquired for either symptomatic workup or asymptomatic follow-up examination of shunt-treated hydrocephalus.

Unintentional ingestion of 60% hydrogen peroxide by a six-year-old child.

Ingestion of industrial-strength hydrogen peroxide is rare. Fatal outcomes have been reported with solutions of 35%. We report a six-year-old boy who unintentionally ingested an unknown quantity of hydrogen peroxide with a concentration of 60%.

Effects of hyperthyroidism on muscle blood flow during exercise in rats.

Hyperthyroidism is associated with exercise intolerance. Previous research, however, has shown that cardiac output is either normal or enhanced during exercise in the hyperthyroid state. We therefore hypothesized that blood flow to working skeletal muscle is augmented in hyperthyroid animals during in vivo submaximal exercise and, consequently, that noncardiovascular factors are responsible for intolerance to exercise.

Receiver operating characteristic analysis of regional cerebral blood flow in Alzheimer's disease.

Receiver operating characteristic (ROC) curves were used to quantitatively assess the ability of individual detectors in a 32-detector 133Xe inhalation system to discriminate between two populations over the range of regional cerebral blood flow (rCBF) values. These populations were clinically evaluated as normal (age 63.1 +/- 13.

Survival in Alzheimer's disease and vascular dementias.

Over 5 years, we followed 199 patients with dementia of the Alzheimer type (DAT), 69 with multi-infarct dementia (MID), and 43 with mixed dementia (MIX). All three diagnostic categories had comparable progression of behavioral and cognitive impairment and need for home care or institutionalization at follow-up. However, 50% survival from diagnosis was 2.

Decreases in amino acids and acetylcholine metabolism during hypoxia.

Hypoxia impairs brain function by incompletely defined mechanisms. Mild hypoxia, which impairs memory and judgment, decreases acetylcholine (ACh) synthesis, but not the levels of ATP or the adenylate energy charge. However, the effects of mild hypoxia on the synthesis of the glucose-derived amino acids [alanine, aspartate, gamma-amino butyric acid (GABA), glutamate, glutamine, and serine] have not been characterized.

Neurotransmitter and carbohydrate metabolism during aging and mild hypoxia.

Alterations in the metabolism of the glucose derived neurotransmitters may underlie some of the deficits in brain function that can accompany aging. We examined the whole brain syntheses of acetylcholine (ACh), alanine, aspartate, glutamate, gamma-aminobutyrate (GABA), glutamine and serine in two strains (C57BL and BALB/c) of aged mice (3, 10 and 30 months). ACh synthesis in C57BL and BALB/c mice declined 41 and 44% at 10 months and 64 and 75% by 30 months.