Publications by authors named "Sanskruti Swain"
Bone metastasis is the primary cause of death among patients with advanced prostate cancer (PCa). PCa tends to spread to bones and acquire the bone-like phenotype, causing osteoblastic bone metastasis. Unfortunately, there is no effective treatment for this condition.
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- Redox imbalance and oxidative stress are linked to serious health issues like neurodegenerative disorders, cancer, and premature aging, making accurate detection of antioxidants important for managing these conditions.
- This study introduces a new fluorescence-based assay that uses dithiothreitol (DTT)-assisted gold nanoclusters (DTT@BSA-AuNCs) to detect antioxidant levels more effectively than traditional methods, which often miss thiol-containing antioxidants.
- The assay can identify antioxidants like ascorbic acid and glutathione at very low concentrations and has proven effective in human saliva and cancer cell models, offering a reliable and cost-effective way to monitor oxidative stress in various diseases.
Advanced prostate cancer often develops into bone metastasis, which is characterized by aberrant bone formation with chronic pain and lower chances of survival. No treatment exists as yet for osteoblastic bone metastasis in prostate cancer. The indolamine melatonin (N-acetyl-5-methoxytryptamine) is a major regulator of the circadian rhythm.
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