Publications by authors named "Sanskruti R Gare"
Article Synopsis
- Obesity leads to lipid accumulation in heart cells (cardiomyocytes), causing stress and heart damage, which can result in heart failure.
- Researchers found that PAK3 levels are higher in the hearts of obese individuals and in mice that are stressed by diet, making them more prone to heart issues due to toxic lipid buildup.
- Knocking down PAK3 can reduce fat-induced toxicity in heart cells, suggesting that targeting PAK3 might be a potential treatment for obesity-related heart problems.
Diabetes is a metabolic disorder with an increased risk of developing heart failure. Inflammation and damaged vasculature are the cardinal features of diabetes-induced cardiac damage. Moreover, systemic metabolic stress triggers discordant intercellular communication, thus culminating in cardiac dysfunction.
View Article and Find Full Text PDFMetabolic syndrome is a chronic systemic disease that is particularly manifested by obesity, diabetes, and hypertension, affecting multiple organs. The increasing prevalence of metabolic syndrome poses a threat to public health due to its complications, such as liver dysfunction and cardiovascular disease. Impaired adipose tissue plasticity is another factor contributing to metabolic syndrome.
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