Publications by authors named "Sanneke A M van Vliet"
Current therapies for Parkinson's disease (PD) like l-dopa and dopamine (DA) agonists have declined efficacy after long term use. Therefore, research towards supplementary or alternative medication is needed. The implementation in PD can be expedited by application of compounds already used in the clinic.
View Article and Find Full Text PDFBackground And Purpose: The effects of sleep deprivation are a burden in our 24-h society. The use of wake-promoting compounds could improve the performance in situations where sleep cannot be allowed. In this study, the efficacy of the wake-promoting compounds, modafinil and caffeine, in counteracting the effects of 24-h sleep deprivation in the marmoset monkey were tested.
View Article and Find Full Text PDFArticle Synopsis
- Modafinil shows protective effects against brain injury and behavior changes in a marmoset model of Parkinson's disease caused by 1-methyl-1,2,3,6-tetrahydropyridine.
- Daily treatment with modafinil (100 mg/kg) over 27 days significantly reduced the negative impacts on behavior, locomotor activity, and hand-eye coordination compared to a vehicle control group.
- Additionally, dopamine levels in the striatum were much higher in the modafinil-treated group, indicating that modafinil may be an effective treatment option for managing symptoms associated with Parkinson's disease.
Behavioral effects of modafinil in marmoset monkeys.
Sanneke A M van Vliet Marjan J Jongsma Raymond A P Vanwersch Berend Olivier Ingrid H C H M Philippens
Psychopharmacology (Berl)
May 2006
Article Synopsis
- Modafinil is being explored not just for enhancing alertness in sleep disorders and neurodegenerative diseases, but also for its potential benefits in healthy individuals, leading to a need for more research on its behavioral effects.
- Observational methods and behavioral tests were conducted on marmoset monkeys to assess modafinil's impacts on various behaviors after administering different doses.
- Results indicated that modafinil increased locomotor activity and exhibited anxiolytic-like effects without causing side effects or affecting hand-eye coordination or startle response, suggesting new therapeutic possibilities for its use.