Publications by authors named "Sanne S Meisser"
Background: p-Phenylenediamine (PPD) is a potent contact allergen found in many hair colour products. However, not all individuals develop allergic contact dermatitis (ACD) although they are regularly exposed to PPD. It is unclear whether these asymptomatic individuals are true non-responders to PPD or whether they mount a response to PPD without showing any symptoms.
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- p-Phenylenediamine (PPD), a common ingredient in hair dyes, can cause allergic contact dermatitis (ACD), prompting a study on its effects on occupationally exposed individuals with and without symptoms.
- The research involved collecting skin samples from patients with varying degrees of ACD and hairdressers, followed by advanced RNA sequencing and protein analysis.
- Results indicated significant downregulation of key skin proteins related to barrier function, particularly in those with severe ACD, suggesting that even asymptomatic exposure to PPD may lead to harmful changes in skin biology.