Publications by authors named "Sanne J J Langmuur"
Article Synopsis
- Normothermic ex situ heart perfusion (ESHP) improves the availability of hearts from donors after circulatory death (DCD), but current methods for assessing heart function, like monitoring lactate levels, are not very effective.* -
- This study evaluated the use of high-resolution cardiac mapping during ESHP to analyze the electrical function of DCD hearts, revealing that lower voltages could indicate myocardial injury.* -
- The results from mapping ten DCD hearts showed that the technique is safe and feasible, and it could provide valuable insights into graft function for marginal donor hearts.*
Article Synopsis
- Normothermic heart perfusion (ESHP) allows for evaluating hearts from donors who experienced circulatory death, highlighting the need for sensitive metrics to gauge heart function before transplantation.* -
- This study introduces electrophysiological (EP) parameters as potential biomarkers for assessing post-ischemic heart performance, using porcine hearts categorized by different warm ischemia durations for analysis.* -
- Findings indicate that hearts affected by prolonged warm ischemia exhibit lower voltage and flatter potential slopes in electrical measurements, which correlate with their contractile performance and could assist in determining the viability of DCD hearts for transplantation.*
Hypertrophic cardiomyopathy (HCM) is the most common inherited myocardial disorder of the heart, but effective treatment options remain limited. Mavacamten, a direct myosin modulator, has been presented as novel pharmacological therapy for HCM. The aim of this study was to analyze the biomechanical response of HCM tissue to Mavacamten using living myocardial slices (LMS).
View Article and Find Full Text PDFAvailable donor organs for lung transplantation are scarce. Ex vivo lung perfusion provides a platform to preserve, assess, and recondition donor lungs and can thereby aid in enlarging the donor pool. This video tutorial discusses the indications, preparation, and surgical technique for and the initiation, maintenance and termination of the ex vivo lung perfusion procedure.
View Article and Find Full Text PDFLiving myocardial slices (LMS) are beating sections of intact human myocardium that maintain 3D microarchitecture and multicellularity, thereby overcoming most limitations of conventional myocardial cell cultures. We introduce a novel method to produce LMS from human atria and apply pacing modalities to bridge the gap between in-vitro and in-vivo atrial arrhythmia studies. Human atrial biopsies from 15 patients undergoing cardiac surgery were dissected to tissue blocks of ~ 1 cm and cut to 300 µm thin LMS with a precision-cutting vibratome.
View Article and Find Full Text PDFPurpose: Multiple randomized controlled trials have presented SGLT2 inhibitors (SGLT2i) as novel pharmacological therapy for patients with heart failure, resulting in reductions in hospitalization for heart failure and mortality. Given the absence of SGLT2 receptors in the heart, mechanisms of direct cardioprotective effects of SGLT2i are complex and remain to be investigated. In this study, we evaluated the direct biomechanical effects of SGLT2i empagliflozin on isolated myocardium from end-stage heart failure patients.
View Article and Find Full Text PDFBackground: The ligament of Marshall (LOM) may play a role in the pathophysiology of several tachyarrhythmias and accurate electrophysiological localization of this structure is crucial for effective ablation therapy. This study therefore quantifies electrophysiological properties of the LOM, and identifies which electrogram (EGM) recording (uni- or bipolar) and processing technologies [local activation time (LAT) and/or voltage mapping] are most suitable for accurate localization of the LOM.
Methods: The LOM was electrophysiologically identified in 19 patients (mean age 66 ± 14 years; 12 male) undergoing elective cardiac surgery using intra-operative high-density epicardial mapping, to quantify and visualize EGM features during sinus rhythm.
Article Synopsis
- Heart transplantation is the best treatment for end-stage heart failure, but there’s a growing gap between the demand for and supply of donor hearts, prompting research into new preservation methods like the Organ Care System (OCS).
- A meta-analysis of 12 studies involving 741 patients showed that using OCS for heart donation after brain death (DBD) or circulatory death (DCD) did not result in different early or long-term survival outcomes compared to traditional cold storage methods.
- The study concluded that OCS is a safe and effective way to increase the availability of donor hearts, benefiting complex surgeries and long-distance transport of organs.