Publications by authors named "Sannah P N Mativandlela"
Article Synopsis
- The study extracted and isolated four flavonoids from the leaves of Galenia africana, including three known compounds and one new compound.
- Two of the compounds, specifically compounds 1 and 3, showed moderate activity against tuberculosis.
- The combination of compound 4 with the antituberculosis drug isoniazid significantly enhanced their effectiveness, indicating a potential for improved treatment strategies.
Seven ethnobotanically selected medicinal plants were screened for their antimycobacterial activity. The minimum inhibitory concentration (MIC) of four plants namely Artemisia afra, Dodonea angustifolia, Drosera capensis and Galenia africana ranged from 0.781 to 6.
View Article and Find Full Text PDFThe naphthoquinone 7-methyljuglone (5-hydroxy-7-methyl-1,4-naphthoquinone) has previously been isolated and identified as an active component of root extracts of Euclea natalensis which displays antitubercular activity. Herein, a series of synthetic and plant-derived naphthoquinone derivates of the 7-methyljuglone scaffold have been prepared and evaluated for antibacterial activity against Mycobacterium tuberculosis. Several of these compounds have been shown to operate as subversive substrates with mycothiol disulfide reductase.
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