Levonorgestrel Microneedle Array Patch for Sustained Release Contraception: Formulation, Optimization and In Vivo Characterization.

Background: The goal of this work was to develop a levonorgestrel liposome-loaded microneedle array patch for contraception.

Methods: Levonorgestrel-loaded liposome was formulated by a solvent injection technique, characterized, and studied.

Results: The formulated liposomes were characterized for particle size (147 ± 8 nm), polydispersity index (0.