Correction: Architecture of the Escherichia coli nucleoid.

[This corrects the article DOI: 10.1371/journal.pgen.

Architecture of the Escherichia coli nucleoid.

How genomes are organized within cells and how the 3D architecture of a genome influences cellular functions are significant questions in biology. A bacterial genomic DNA resides inside cells in a highly condensed and functionally organized form called nucleoid (nucleus-like structure without a nuclear membrane). The Escherichia coli chromosome or nucleoid is composed of the genomic DNA, RNA, and protein.

Draft Genome Sequence of the Naturally Competent Strain WY10.

We sequenced a naturally competent bacterial isolate, WY10, cultured from a Wyoming soil sample. Sequence analysis revealed that WY10 is a novel strain of To our knowledge, WY10 is the first strain to be characterized as naturally competent for DNA uptake by transformation.

Novel "Superspreader" Bacteriophages Promote Horizontal Gene Transfer by Transformation.

Unlabelled: Bacteriophages infect an estimated 10 to 10 bacterial cells each second, many of which carry physiologically relevant plasmids (e.g., those encoding antibiotic resistance).

The prospect for bacteriophage therapy in Western medicine.

Bacteriophage (phage) have been used for clinical applications since their initial discovery at the beginning of the twentieth century. However, they have never been subjected to the scrutiny--in terms of the determination of efficacy and pharmacokinetics of therapeutic agents--that is required in countries that enforce certification for marketed pharmaceuticals. There are a number of historical reasons for this deficiency, including the overshadowing discovery of the antibiotics.