Comparative analysis of mangiferin against conventional drugs for skin cancer and inflammation: integrating and studies.

Sun persuades excess ROS production in the skin, altering pro-inflammatory factors and cellular responses, thereby contributing to the progression of skin disorders and skin cancer. In this study, the non-animal, and methods have been employed to interpret the potential of bioactive mangiferin against skin inflammation and skin cancer. In the approach, auto blind docking tool CB Dock 2 was utilized to assess and compare the efficacy of mangiferin against some conventional drugs like aspirin, diclofenac, betamethasone for inflammation and with 5-fluorouracil, docetaxel, doxorubicin, imiquimod, paclitaxel, sonidegib, vincristine and vismodegib for skin cancer.

Development and Evaluation of a Broad spectrum Polyherbal Sunscreen formulation using Solid Lipid Nanoparticles of Safranal.

Introduction: UV absorption properties of bioactive agents has led to their screening and development to provide photoprotection. Safranal is one such secondary plant metabolite obtained from Saffron (Crocus sativus) and reported to possess antioxidant and antisolar properties. The objective of this research was to design a suitable delivery system for the topical delivery of Safranal and to develop broad-spectrum polyherbal sun protection cream with mild photoprotection.

Insights into the mechanism of essential oil in topical therapy of acne vulgaris.

The present study investigated the essential oil of (palmarosa oil; PRO) as a potential topical therapy in acne vulgaris. GC-MS profiling and biocompatibility studies of PRO were undertaken. The antimicrobial potential was assessed against anti-inflammatory, antityrosinase activity and lipid peroxidation were also evaluated.

The role of Safranal and saffron stigma extracts in oxidative stress, diseases and photoaging: A systematic review.

Reactive oxygen species (ROS) are produced as a result of various environmental factors and cellular metabolism reactions creating oxidative stress. The reversible oxidative modification on proteins such as cysteine oxidation may be useful and can play positive role. ROS generated offer some benefits such as cellular signalling and tissue repair when present in low concentration.

Statistical development and evaluation of resveratrol-loaded topical gel containing deformable vesicles for a significant reduction in photo-induced skin aging and oxidative stress.

Objective: The present study aims to formulate and evaluate a novel vesicular formulation of resveratrol to achieve its dermatological benefits in terms of antiphotoaging and antioxidant.

Method: In this study, resveratrol-loaded deformable vesicular gel was prepared and optimized using Box-Behnken design. Selected critical material attributes were amount of phospholipid (X1), concentration of ethanol (X2), and amount of sodium cholate (X3).

Microsponges for dermatological applications: Perspectives and challenges.

Dermatological disorders have a huge psychosocial impact, causing significant impairment of patient's life. Topical therapy plays a pivotal role in management of such disorders. Conventional topical delivery systems result in overmedication/undermedication, leading to adverse effects and reduction in therapeutic efficacy.

Cubosome: A Potential Liquid Crystalline Carrier System.

Cubosome is a biocompatible, thermodynamically stable and bioadhesive drug carrier that is prepared from certain amphiphilic lipids and surfactants when mixed in a definite ratio. Structurally, they are selfassembled nano-constructed liquid crystalline particles comprising three-dimensionally arranged bicontinuous as well as nonintersecting lipid bilayers that give them a honeycomb-like appearance. Morphological characterization through SAXS (small-angle X-ray scattering) and cryo-TEM (cryo-transmission electron microscopy) revealed that they are square and round shaped particles in the nanometer range.

Analytical tools and evaluation strategies for nanostructured lipid carrier-based topical delivery systems.

Introduction: The inception of nanostructured lipid carriers (NLCs) proved to be a revolutionary step toward the treatment of dermatological disorders. To uncover its true potential, it is imperative that the system be characterized and evaluated comprehensively.

Areas Covered: The present review has been written to furnish an in-depth account of analytical tools and evaluation procedures under one roof.

Immunomodulatory Properties of Chitosan: Impact on Wound Healing and Tissue Repair.

Objective: Chitosan, a natural polymer from shelled crustaceans, has been employed in an array of biomedical applications as it possesses a combination of fascinating attributes such as biocompatibility, biodegradability, non-toxicity and ease of chemical alteration into different active derivatives. The ability of chitosan to be tailored into different shapes has made it a very popular polymer for designing novel drug delivery systems for topical, transdermal and gene delivery. Recently, the multifunctional and immunomodulatory properties of chitosan have attracted a lot of attention.

Quality by design driven development of resveratrol loaded ethosomal hydrogel for improved dermatological benefits via enhanced skin permeation and retention.

Resveratrol is a potent anti-oxidant agent and can be used for the effective management of different skin conditions like extrinsic skin ageing, psoriasis, etc. The objective of this research was to develop a dermal delivery system of resveratrol for its improved dermatological benefits for achieving its enhanced skin deposition profile with limited systemic exposure. Resveratrol loaded ethosomal hydrogel was developed and optimized using systematic Quality by Design approach.

Recent Advances in Nanosuspension Technology for Drug Delivery.

Background: Discovery and development of BCS class 1 drugs through high throughput screening is one of the biggest challenge faced by formulation scientist.

Methods: There are a number of approaches that have been exploited to enhance the solubility and permeability of drugs. Among them, development of nanosuspension has offered several benefits.

In-vitro evaluation of antioxidant, anti-elastase, anti-collagenase, anti-hyaluronidase activities of safranal and determination of its sun protection factor in skin photoaging.

Safranal, a monoterpene aldehyde, is present as one of the main volatile constituents of Crocus sativus Linn. (saffron flowers). This volatile constituent not only contributes to the aroma of saffron but has been reported to possess antidiabetic, antiulcer, antiasthamatic, anticonvulsant, antidepressant, cardioprotective, anticancer and UV protective properties.

Systematically Optimized Ketoprofen-Loaded Novel Proniosomal Formulation for Periodontitis: In Vitro Characterization and In Vivo Pharmacodynamic Evaluation.

Various preclinical/clinical studies support the effectiveness of ketoprofen in periodontitis; however, the literature reveals that novel delivery systems have been less explored for the drug in periodontitis. The current investigation aims to explore the potential of a pro-vesicular approach-based proniosomal drug delivery of ketoprofen for its effectiveness and validation in experimental periodontal disease (EPD). Formulations were developed using I-optimal mixture design.

Analgesic Prodrugs for Combating their Side-Effects: Rational Approach.

Background: Analgesics are the drugs which bring insensibility to pain without loosing consciousness. Treatment strategy is generally based on the type of pain. Most of the analgesics are associated with serious side effects, such as NSAIDS can cause severe GI disturbance and opioids can cause addiction.

Novel Carriers for Coenzyme Q10 Delivery.

Background: Coenzyme Q10, a natural yellow benzoquinone, is a vitamin-like substance commonly found in blood and inner mitochondrial and cellular membranes. It is a natural antioxidant principle which plays an essential role in maintaining several biochemical pathways of body. It has exhibited many pharmacological activities in chronic heart failure, cardiofaciocutaneous syndrome, diabetes mellitus, carcinomas, autoimmune disease, cataract, asthma, periodontal disease and thyroid disorders.

QbD-Based Development and Validation of a Stability-Indicating HPLC Method for Estimating Ketoprofen in Bulk Drug and Proniosomal Vesicular System.

The current studies entail systematic quality by design (QbD)-based development of simple, precise, cost-effective and stability-indicating high-performance liquid chromatography method for estimation of ketoprofen. Analytical target profile was defined and critical analytical attributes (CAAs) were selected. Chromatographic separation was accomplished with an isocratic, reversed-phase chromatography using C-18 column, pH 6.

Systematically optimized coenzyme q10-loaded novel proniosomal formulation for treatment of photo-induced aging in mice: characterization, biocompatibility studies, biochemical estimations and anti-aging evaluation.

Environmental stress and advancing age is considered as the main cause of skin aging. However, environmental stress (especially UV radiations) accelerates the process of skin aging by manifolds. Coenzyme Q10 (CoQ10), an essential compound of cellular bioenergetics also acts as a strong antioxidant and protects the body against aging.

Transdermal innovations in diabetes management.

Diabetes mellitus, an endocrine disorder affecting glucose metabolism, has been crippling mankind for the past two centuries. Despite the advancements in the understanding pertaining to its pathogenesis and treatment, the currently available therapeutic options are far from satisfactory. The growing diabetic population increases the gravity of the situation.

A validated high performance liquid chromatographic method for estimation of bromhexine and terbutaline in bulk and tablet dosage forms.

Introduction: Bromhexine (BH) is a mucolytic agent used in the treatment of respiratory disorders marketed in combination with terbutaline (TB), a β2-adrenergic receptor agonist used as a fast-acting bronchodilator.

Materials And Methods: BH and TB were estimated at 270 nm by using ODS C8 column (length 250 mm and internal diameter 4.6 mm) as a stationary phase and a premix of phosphate buffer (0.

Spectrophotometric estimation of solifenacin succinate in tablet formulations.

Aim: The aim of this study is to develop a simple, sensitive, rapid, accurate, and precise spectrophotometric method for the estimation of solifenacin succinate in tablet dosage forms.

Materials And Methods: For methods I and II, in a series of 10 ml volumetric flasks, aliquots of standard drug solution (100 μg/ml) in double distilled water were transferred and diluted with the same so as to give several dilutions in the concentration ranges of 10 - 60 μg/ml and 10 - 60 μg/ml, respectively, of solifenacin succinate. To 5 ml of each dilution taken in a separating funnel, (5 ml of bromo thymol blue for method I and 5 ml of bromo phenol blue for method II) reagent and 5 ml of chloroform were added.

Spectrophotometric estimation of betahistine hydrochloride in tablet formulations.

Aim: The study aims to develop simple, sensitive, rapid, accurate and precise spectrophotometric method for estimation of Betahistine hydrochloride in tablet dosage forms.

Materials And Methods: For method I and II, in a series of 10 ml volumetric flask, aliquots of standard drug solution (100 μg/ml) in double distilled water were transferred and diluted with same so as to give several dilutions in concentration range of 15-90 μg/ml and 10-80 μg/ml respectively of betahistine hydrochloride. To 5 ml of each dilution taken in a separating funnel, (5 ml of methyl orange for method I and 5 ml of bromo phenol blue for method II) reagent and 5 ml of chloroform was added.

Sonophoresis: recent advancements and future trends.

Objectives: Use of ultrasound in therapeutics and drug delivery has gained importance in recent years, evident by the increase in patents filed and new commercial devices launched. The present review discusses new advancements in sonophoretic drug delivery in the last two decades, and highlights important challenges still to be met to make this technology of more use in the alleviation of diseases.

Key Findings: Phonophoretic research often suffers from poor calibration in terms of the amount of ultrasound energy emitted, and therefore current research must focus on safety of exposure to ultrasound and miniaturization of devices in order to make this technology a commercial reality.