Therapeutic potentials of (L.) O.Kuntze evidenced into an array of pharmacological effects and ligand-receptor interactions.

This study constructed the phytochemical profiles of Adenostemma lavenia (L) methanol extract (MEAL) and investigated its anti-nociceptive, anti-diarrheal, antipyretic, thrombolytic and anthelmintic effects. The GC-MS characterized MEAL had undergone an antipyretic effect assayed on Swiss albino mice adopting the yeast-induced pyrexia model, antinociceptive activity tested following acetic acid-induced writhing and formalin-induced licking paw models, anti-diarrheal effect in castor oil-induced diarrhea, castor oil-induced enteropooling, and charcoal-induced intestinal transit tests, thrombolytic effect using clot-lysis model and anthelmintic effects assayed on nematode. The MEAL biometabolites and associated proteins of target diseases were interacted with computational analysis.

Pharmacological insights into Chukrasia velutina bark: Experimental and computer-aided approaches.

Background: Chukrasia velutina is an enthnomedicinally used plant reported to have significant medicinal values. The present study aimed to explore the pharmacological activities of bark methanol extract using in vitro, in vivo and in silico models.

Methods: The study was designed to investigate the pharmacological effects of methanol extract of Chukrasia velutina bark (MECVB) through in vitro, in vivo and in silico assays.

GC-MS Phytochemical Profiling, Pharmacological Properties, and In Silico Studies of Leaves: A Novel Source for Bioactive Agents.

is a local medicinal plant commonly known as chikrassy in Bangladesh, India, China, and other South Asian countries. The leaves, bark, and seeds are vastly used as herbal medicine for fever and diarrhea, and its leaves essential oils are used for antimicrobial purposes. In this study, we discuss the neuropsychiatric properties of leaves through several animal models, quantitative and qualitative phytochemical analysis, and computational approaches.