Publications by authors named "Sanjib Kumar Sahu"
Article Synopsis
- * The study analyzes polymorphisms in CASP8 and CASP3 genes among 300 CAD patients and 300 healthy controls, using genetic testing methods to identify variations linked to disease risk.
- * Findings indicate that certain genotypes of CASP8 and CASP3 are associated with an increased risk of CAD, suggesting these polymorphisms could serve as genetic markers for the disease.
Genetic polymorphisms of eNOS (-786T/C, Intron 4b/4a & 894G/T) and its association with asymptomatic first degree relatives of coronary heart disease patients.
Nitric Oxide
November 2016
Article Synopsis
- - The study investigates the genetic variations of the eNOS gene (specifically the -786T/C, Intron 4b/4a, and 894G/T polymorphisms) and their link to the higher prevalence of Coronary Heart Disease (CHD) among young Indians and their first-degree relatives (FDRS).
- - Results reveal that FDRS and CHD patients exhibit significantly higher risk factors (like obesity and family history) compared to healthy controls, alongside notable differences in eNOS genotype frequencies.
- - The findings highlight the critical role of eNOS variations in CHD development and suggest potential for predicting coronary risks and developing preventative treatments for at-risk individuals.
Coronary artery disease (CAD) remains to be the prominent health problem in India, and its incidence is growing in developing countries as well. Matrix metalloproteinase 1 (MMP 1) is highly expressed in disruption-prone shoulder regions of the fibrous plaques. The present study aims to investigate association of MMP 1 gene polymorphisms (-1607 1G/2G) and serum circulating levels with CAD.
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- Coronary Artery Disease (CAD) is a major global health issue caused by the buildup of lipid-rich plaques in the arteries, and atorvastatin is a commonly used statin for managing cholesterol levels and reducing cardiovascular risks.
- * The study aimed to assess the effectiveness of atorvastatin on lipid profiles and DNA damage in CAD patients by comparing results before and after 6 months of treatment with a control group.
- * Results showed that atorvastatin significantly improved lipid profiles and reduced DNA damage in CAD patients, suggesting potential benefits in disease management.
Aim: Atherosclerosis, the underlying pathology of cardiovascular disease, is a common, multifactorial disorder with both genetic and environmental components as risk factors. Gelatinase B, also known as MMP-9, is one of the matrix metalloproteinases that is highly expressed in the disruption-prone regions of atherosclerotic plaques. It has been hypothesized that a genetic variation affecting the expression or activity of MMP-9 influences the susceptibility and progression of atherosclerosis.
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