Publications by authors named "Sanji Kanaoka"
Article Synopsis
- - LAT1 is a protein that helps transport important amino acids and is linked to cancer growth, particularly in castration-resistant prostate cancer (CRPC), where it is highly expressed.
- - The study utilized JPH203, a LAT1 inhibitor, which significantly reduced leucine uptake and inhibited CRPC cell growth, migration, and invasion, while having little effect on castration-sensitive LNCaP cells.
- - RNA sequencing revealed that JPH203 downregulated CD24 in CRPC cells, interfering with the Wnt/β-catenin signaling pathway, suggesting that JPH203's potential anticancer effects are linked to mTOR signaling and CD24 modulation.
Epigenetic modifiers are upregulated during the process of prostate cancer, acquiring resistance to castration therapy and becoming lethal metastatic castration-resistant prostate cancer (CRPC). However, the relationship between regulation of histone modifications and chromatin structure in CRPC has yet not fully been validated. Here, we reanalyzed publicly available clinical transcriptome and clinical outcome data and identified NSD2, a histone methyltransferase that catalyzes H3K36me2, as an epigenetic modifier that was upregulated in CRPC and whose increased expression in prostate cancer correlated with higher recurrence rate.
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