The selection of tandem angle and imaging during intracavitary brachytherapy of carcinoma cervix - An experience from a regional cancer center.

Introduction: Carcinoma cervix (CACX) is a common gynecological malignancy and locally advanced CACX is treated with radical chemoradiation, followed by brachytherapy boost. The appropriate selection of tandem angle is needed for optimal dose distribution and to avoid perforations. The aim of our study was to assess the appropriate tandem angle selection based on uterine angle measured on external beam radiotherapy (EBRT) planning imaging and to assess the need for repeat imaging and image-guided placement of tandem during intracavitary brachytherapy based on risk factors.

Significance of Combined Analysis of High-Risk Human Papillomaviruses Polymerized Chain Reaction Analysis and Immunohistochemical Expression of p16INK4A in Cervical Cancer in a Cohort of South-Indian Population.

Introduction Cervical cancer is the fourth most frequent cancer in women worldwide, and it continues to be a big issue in developing countries. The current case-control study sought to determine the presence of high-risk human papillomaviruses (hr-HPV) in the development of cervical cancer, as well as their relationship with the cell cycle inhibitor gene p16INK4A in cervical cancer. Methods The association between p16INK4A protein and the presence of hr-HPV DNA in cervical lesions was explored in this study, which included 150 cervical cancer patients and 100 normal cervix samples.

Genotypic and haplotype analysis of Interleukin-6 and -18 gene polymorphisms in association with clinicopathological factors in breast cancer.

Cytokines are multifunctional glycoproteins that play a vital role in the tumor microenvironment and progression of breast cancer. Genetic polymorphisms may influence the immune responses restrained by pro- and anti-inflammatory cytokine expression in tumors. Hence, the present study evaluated the contribution of Interleukin (IL) 6 (rs1800797, rs1800796, and rs1800795) and IL18 (rs1946518, rs187238, and rs549908) genotypes and their haplotypes to the risk, progression of breast cancer in South Indian population.

Evaluation of Rare Types of Breast Cancer among Indian Patients - a Retrospective Study from a Regional Cancer Center.

Introduction: Breast cancer (BC) is the most common cancer among Indian women and invasive duct cell carcinoma (IDCC) the most common histology (80-90%) followed by noninvasive duct cell carcinoma (non-IDCC) subtypes (about 10%). Most of the non-IDCC are rare (<1-2%), and literature on this topic is sparse. Age is an important prognostic factor and varies with ethnicity.

Should we consider thyroid gland as an organ at risk in carcinoma breast patients receiving adjuvant radiation by conformal technique? A single institute dosimetric study.

Background: The most common malignancy among Indian women is carcinoma of the breast. In the management of breast cancer (BC), radiation therapy (RT) is given to breast or chest wall and supraclavicular lymph nodal (SCLN) area, with at least part of the thyroid receiving RT dose.There is an increased incidence of hypothyroidism (HT) among BC patients after RT involving the SCLN area.

Recommendations to Support Nurses and Improve the Delivery of Oncology and Palliative Care in India.

Context: Nurses in India often practice in resource-constrained settings and care for cancer patients with high symptom burden yet receive little oncology or palliative care training.

Aim: The aim of this study is to explore challenges encountered by nurses in India and offer recommendations to improve the delivery of oncology and palliative care.

Methods: Qualitative ethnography.