Clinical profile of hemophilia B patients from Karnataka.

Background: The most prevalent severe inherited hemorrhagic condition is hemophilia, which means "love of blood." Hemophilia A and B are caused by a lack or malfunction of the factor VIII and factor IX proteins.

Objective: The present study is to determine the prevalence and clinical profile of hereditary coagulation disorder, particularly hemophilia B, in Karnataka.

Mutation analysis and characterisation of gene in haemophilia- B population of India.

Background: Hemophilia B (HB) is an X-linked bleeding disorder resulting from coagulation factor IX defects. Over 3,000 pathogenic, HB-associated mutations in the gene have been identified. We aimed to investigate the role of variants in 150 HB patients using sequencing technology.

Suboccipital retrosigmoid surgical approach for internal auditory canal--a morphometric anatomical study on dry human temporal bones.

Suboccipital retrosigmoid craniotomy with removal of posterior wall of internal auditory canal is preferred by many surgeons operating on acoustic neuromas, as it is a simple and safe approach. To study the topographic landmarks of the posterior surface of the temporal bone. We studied the surgical anatomy of 224 dry adult human temporal bones, measured the various distances on posterior wall of petrous bone relevant for suboccipital surgical approach to internal auditory canal.