Publications by authors named "Sanjeev Janarthanan"
Article Synopsis
- Some individuals react differently to chronic stress, with some being more susceptible while others display resilience.
- This study focuses on the lateral habenula (LHb), which is involved in signaling negative outcomes, to see how its activity differs between susceptible and resilient mice during stress.
- Findings reveal that susceptible mice exhibit increased LHb activity during stress, particularly when near aggressors, leading to long-lasting effects on brain activity and behavior that promote further susceptibility.
Article Synopsis
- - The study investigates how different mice respond to chronic stress, focusing on the lateral habenula (LHb), which is linked to negative learning signals.
- - Researchers found that susceptible mice show greater LHb activity when near aggressive mice after experiencing social defeat stress, contributing to their susceptibility.
- - The increased LHb activity during stress leads to widespread changes in brain function in susceptible mice, resulting in lasting impacts on their behavior and neural responses.
Animals learn the value of foods based on their postingestive effects and thereby develop aversions to foods that are toxic and preferences to those that are nutritious. However, it remains unclear how the brain is able to assign credit to flavors experienced during a meal with postingestive feedback signals that can arise after a substantial delay. Here, we reveal an unexpected role for postingestive reactivation of neural flavor representations in this temporal credit assignment process.
View Article and Find Full Text PDFThe cerebellum regulates nonmotor behavior, but the routes of influence are not well characterized. Here we report a necessary role for the posterior cerebellum in guiding a reversal learning task through a network of diencephalic and neocortical structures, and in flexibility of free behavior. After chemogenetic inhibition of lobule VI vermis or hemispheric crus I Purkinje cells, mice could learn a water Y-maze but were impaired in ability to reverse their initial choice.
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