Publications by authors named "Sanjeet Kumar Jaiswal"
This study aimed to compare the sensitivity of Ga-DOTATATE positron emission tomography/computed tomography (PET/CT) with other imaging modalities in the detection of head and neck paraganglioma (HNPGL). The data of consecutive HNPGL patients ( = 34) who had undergone at least Ga-DOTATATE PET/CT and anatomical imaging (contrast-enhanced computed tomography/magnetic resonance imaging [CECT/MRI]) were retrospectively reviewed. The diagnosis of HNPGL (the primary tumor) was confirmed either by histopathology ( = 10) or was based on clinical follow-up and correlation of anatomical with functional imaging in whom histopathology was not available ( = 24).
View Article and Find Full Text PDFBackground: Liraglutide in a 3.0 mg subcutaneous dose daily is approved for weight reduction.
Objectives: Objectives are to evaluate the efficacy and safety of liraglutide 3.
The main objective of this systematic review and meta-analysis was to review, assess and report on the studies that have evaluated selective alpha blockade (SAB) vs. non-selective alpha blockade (NSAB) therapy in patients undergoing surgery for pheochromocytomas and paragangliomas (PPGL). We performed a systematic search of electronic databases.
View Article and Find Full Text PDFPurpose: Pheochromocytoma and paraganglioma (PGL), together called PPGL, are rare tumors with a limited number of studies on the diagnostic performance of Ga-DOTA (0)-Tyr (3)-octreotate positron emission tomography-computed tomography (Ga-DOTATATE PET/CT) from the Asian-Indian subcontinent.
Materials And Methods: In this retrospective study, PPGL suspects ( = 87) who had undergone at least contrast-enhanced computed tomography (CECT) and Ga-DOTATATE PET/CT, were included. Lesion-wise, patient-wise, and region-wise sensitivities of Ga-DOTATATE PET/CT, F fluorodeoxyglucose positron emission tomography CT (F-FDG PET/CT, = 53), I-metaiodobenzylguanidine (I-MIBG, = 37), and CECT were compared, and diagnostic performance of Ga-DOTATATE PET/CT in the detection of PPGL was calculated.
Article Synopsis
- Radionuclide therapy, specifically low-dose, low-specific activity (LSA) I-metaiodobenzyl guanidine (I-MIBG), is being studied for its safety and effectiveness in treating symptomatic, metastatic pheochromocytoma/paraganglioma (PPGL) in patients from the Indian subcontinent.
- A retrospective review of 17 patients showed varying degrees of response to the therapy: 18% achieved complete remission, 24% had partial remission, while 41% experienced disease progression. Side effects were noted in some patients, including serious conditions like thrombocytopenia and acute myeloid leukemia.
- The study suggests that while LSA I-MIBG therapy demonstrates modest efficacy and safety
Context: Preoperative blockade with α-blockers is recommended in patients with pheochromocytoma/paraganglioma (PPGL). The data on calcium channel blockade (CCB) in PPGL are scarce.
Objective: We aimed to compare the efficacy of CCB and α-blockers on intraoperative hemodynamic instability (HDI) in PPGL.
The data from the Indian subcontinent on Medullary thyroid carcinoma (MTC) and associated endocrinopathies in hereditary MTC (HMTC) syndromes are limited. Hence, we analyzed clinical and biochemical characteristics, management, and outcomes of HMTC and other associated endocrinopathies [Pheochromocytoma (PCC) and Primary hyperparathyroidism (PHPT)] and compared with apparently sporadic MTC. The records of 97 (51 sporadic and 46 hereditary) consecutive MTC patients were retrospectively analyzed.
View Article and Find Full Text PDFObjective: To study the effect of prior testosterone replacement therapy (TRT) on the spermatogenic response to combined gonadotropin therapy (CGT) in severe and partial phenotype congenital hypogonadotropic hypogonadism (CHH) patients.
Design: Retrospective cohort study.
Setting: Tertiary care center.
Objectives: Pediatric pheochromocytoma and paraganglioma (PPGL) are rare tumors with limited data on the diagnostic performance of Ga-DOTA(0)-Tyr(3)-octreotate positron emission tomography-computed tomography (Ga-DOTATATE PET/CT). We have described our experience of Ga-DOTATATE PET/CT in overall and von Hippel Lindau (VHL)-associated pediatric PPGL and compared its sensitivity with that of I-meta-iodobenzyl-guanidine (I-MIBG), F-fluorodeoxyglucose PET/CT (F-FDG PET/CT), and contrast-enhanced CT (CECT).
Methods: Retrospective evaluation of consecutive PPGL patients (age: ≤20 years), who had undergone at least one functional imaging [I-MIBG, F-FDG PET/CT, and/or Ga-DOTATATE PET/CT], was done.
Context: Data are limited regarding prevalence, predictors, and mechanisms of persistent hypogonadotropic hypogonadism (HH) in males with a macroprolactinoma who achieve normoprolactinemia on dopamine-agonist therapy. None of the previous studies provide cutoffs to predict the achievement of eugonadism.
Objective: The objective of this work is to evaluate the prevalence of persistent HH and its determinants in men with a macroprolactinoma who achieve normoprolactinemia on cabergoline monotherapy.
Introduction: 177Lu-DOTATATE-based peptide receptor radionuclide therapy (PRRT) is a promising therapy for metastatic and/or inoperable pheochromocytoma and paraganglioma (PPGL). We aim to evaluate the efficacy and safety of and identify predictors of response to 177Lu-DOTATATE therapy in metastatic and/or inoperable PPGL.
Methods: This retrospective study involved 15 patients of metastatic or unresectable PPGL, who received 177Lu-DOTATATE PRRT therapy.
Context: Insulinoma needs accurate preoperative localization for minimally invasive surgery. Exendin-4-based imaging has shown promising results.
Objective: To evaluate performance parameters of exendin-4-based imaging in insulinoma localization and compare with other imaging modalities.
Objective: Most of the Indian studies on pheochromocytoma/paraganglioma (PCC/PGL) have focused on PCC, and there is a paucity of information regarding sympathetic paraganglioma (sPGL). Here, we describe the clinical, biochemical, and imaging features of sPGL compared with PCC.
Methods: This retrospective study included 75 patients with sPGL and 150 patients with PCC.