Publications by authors named "Sanjay Vallabhaneni"
Article Synopsis
- * Methodology: Researchers reviewed health records from 2014 to 2022, comparing patients on SGLT-2is to those on other diabetes medications in terms of urology visits, diagnoses, and prescriptions for lower urinary tract symptoms (LUTS).
- * Results: Patients on SGLT-2is had higher rates of urologic issues like urinary urgency and incontinence, especially in those with higher blood sugar levels (HbA1c ≥7%). The study concluded that S
Purpose: Minimally invasive kidney autotransplantation (KAT) has demonstrated reduced morbidity, however multiport robotic approach required patient repositioning and multiple sets of incisions. We present our initial series of single-port (SP) robotic KAT, ideal for multi-quadrant surgeries, and aim to evaluate feasibility and safety of the novel approach.
Methods: Between 2018 and 2022, 8 consecutive patients underwent SP KAT using the DaVinci SP platform.
Although tyrosine kinase inhibitors (TKIs) have demonstrated significant efficacy in advanced lung adenocarcinoma (LUAD) patients with pathogenic alterations in EGFR, most patients develop acquired resistance to these agents via mechanisms enabling the sustained activation of the PI3K and MAPK oncogenic pathways downstream of EGFR. The tumor suppressor protein phosphatase 2A (PP2A) acts as a negative regulator of these pathways. We hypothesize that activation of PP2A simultaneously inhibits the PI3K and MAPK pathways and represents a promising therapeutic strategy for the treatment of TKI-resistant LUAD.
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