Publications by authors named "Sanjay Sunil Kumar"
Article Synopsis
- BACE1 is a key target for Alzheimer's treatment, but existing drugs also affect BACE2, a related protease with unclear functions.
- Researchers found that BACE2 is responsible for shedding VEGFR3, a receptor linked to lymphatic growth; blocking BACE2 increases the receptor levels and its signaling in lymphatic cells.
- This study highlights sVEGFR3 as a valuable blood marker for BACE2 activity, paving the way for safer Alzheimer's drugs that selectively inhibit BACE1.
Article Synopsis
- Researchers have discovered a new cannabinoid receptor (CBR) agonist called LEI-102, used alongside other CBR ligands to understand how these compounds activate the receptor.
- The study reveals important molecular details, including specific residues necessary for CBR activation and the differences in how various ligands reach the receptor's binding site.
- Findings also indicate that LEI-102’s favorable chemical properties allow it to be effective orally in a model of kidney damage caused by chemotherapy, suggesting implications for future drug design targeting GPCRs.
