Publications by authors named "Sanjay Ramachandran"

Article Synopsis
  • Hand, foot, and mouth disease (HFMD) is a childhood infection primarily caused by enteroviruses, characterized by fever and a rash on hands, feet, and mouth, with changing virus types observed in South India from 2015 to 2017.
  • In a study analyzing samples from suspected HFMD cases, CVA6 was identified as the most common virus (64% of cases), followed by CVA16 and CVA10, while 20% of cases could not be typed.
  • The majority of affected individuals were children under five years old, indicating a strong prevalence in young children during this period.
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Background: This study was carried out to understand the circulating genotypes of Hepatitis A virus (HAV) in South West, East and North East India during the period 2017-2018 as a part of acute febrile illness surveillance at the Manipal Institute of Virology.

Methods: Archived serum samples of 48 Hepatitis A confirmed cases were subjected to RNA extraction using QIAamp® Viral RNA Mini Kit (QIAGEN, Germany). The samples with molecular confirmation for HAV by reverse transcriptase real-Time PCR (Real Star® HAV RT-PCR Kit 2.

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Article Synopsis
  • EV-D68 is a new enterovirus linked to serious respiratory issues and paralysis, with few cases reported globally, including one in India.
  • The study analyzed throat swab samples from patients in South India to identify and classify enteroviruses, discovering three cases of EV-D68 in young children with pneumonia but no neurological problems.
  • The findings show that the EV-D68 strains belong to a new subclade (B3) and highlight the need for better surveillance of this virus in India.
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Purpose: Hepatitis E virus (HEV) is an emerging pathogen causing acute viral hepatitis worldwide. Clinical manifestations often occur in young adults with an increased mortality rate among pregnant women. HEV genotypes 1 and 4 are mainly reported among humans and swines, respectively.

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Dengue is the most prevalent arboviral disease affecting humans, with tropical and subtropical regions having the highest risk of dengue virus infections. The clinical symptoms often range from mild fever to fever with hemorrhagic manifestations and shock. Since 2010, India has been witnessing a marked increase in the number of dengue virus serotype 1 (DENV-1) infections, apart from those of serotypes 2 (DENV-2) and 3 (DENV-3).

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