Unraveling the Role of Deep Eutectic Solvents with Varying Hydrogen-Bond Acceptors on the Thermoresponsive Polymer Poly(-isopropylacrylamide).

Deep eutectic solvents (DESs) have emerged as promising tools for crafting polymeric materials across diverse domains. This study delves into the impact of a series of DESs on the phase behavior of poly(-isopropylacrylamide) (PNIPAM) in aqueous environments, presenting compelling insights into their performance. Specifically, we explore the conformational phase behavior of PNIPAM in the presence of four distinct lactic acid (LA)-based DESs: LA-betaine (LA-BET), LA-proline (LA-PRO), LA-choline chloride (LA-CC), and LA-urea (LA-U).

The attenuating ability of deep eutectic solvents towards the carboxylated multiwalled carbon nanotubes induced denatured β-lactoglobulin structure.

The stabilization of proteins has been a major challenge for their practical utilization in industrial applications. Proteins can easily lose their native conformation in the presence of denaturants, which unfolds the protein structure. Since the introduction of deep eutectic solvents (DESs), there are numerous studies in which DESs act as promising co-solvents that are biocompatible with biomolecules.

Impact of ZIF-8, ArgHCl, and Ionic Liquid-Based Formulations on the Conformational and Colloidal Stability of Antibodies.

Various formulations consisting of biomaterials zirconium imidazolate framework-8 (ZIF-8), choline acetate ([Ch][Ac]), and arginine hydrochloride (argHCl) are optimized to study the stability of antibody, Immunoglobulin G (IgG). We have performed several instrumentations including UV-visible spectroscopy, dynamic light scattering (DLS), circular dichroism (far UV CD), and atomic force microscopy (AFM) in the presence of all the formulations to investigate the conformational and colloidal stability of the antibodies. Alongside, the packing efficiency of all the formulations was also explored by storing IgG at 4 °C for 3 months.

Smart Anisotropic Colloidal Composites: A Suitable Platform for Modifying the Phase Transition of Diblock Copolymers by Gold Nanoparticles.

Surface modification of metallic nanoparticles (NPs) by stimuli-responsive polymers is a benign method to prepare smart colloidal composites which tune the characteristic properties of individual systems. The temperature-dependent transition of diblock copolymer poly(-isopropylacrylamide)-block-poly(-vinylcaprolactam) (PNIPMA-b-PVCL) synthesized using reversible addition-fragmentation chain transfer polymerization was studied by incorporating anisotropic gold NPs (AGPs) such as spheres (AuNSs), rods (AuNRs), cubes (AuNCs), and rhombic dodecahedrals (AuRDs). Shape-dependent physiochemical properties of nanostructures alter the lower critical solution temperature (LCST) of the chemical inhomogeneous diblock copolymer.