Publications by authors named "Sanjay Gawade"
Terminal thyroid gland differentiation - the last developmental step needed to enable thyroid hormone (T4) synthesis - involves profound structural and biochemical changes in the thyroid follicular cells (TFCs). We aimed to develop an ex vivo thyroid model of embryonic mouse thyroid that would replicate the in vivo TFC differentiation program. E13.
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- Scientists found out that three new gene changes can cause a problem called thyroid dysgenesis (TD), which affects how the thyroid works.
- These changes were discovered in three families and are pretty rare, making up only 1.1% of the mutated cases studied.
- The research shows that these gene changes can mess up the thyroid's ability to grow and release important hormones, and they also affect how blood platelets work, which can lead to other health issues.
Background: The thyroid is composed of endocrine epithelial cells, blood vessels, and mesenchyme. However, no data exist thus far on absolute cell numbers, relative distribution, and proliferation of the different cell populations in the developing and mature thyroid. The aim of this study was therefore to establish a flow cytometry protocol that allows detection and quantification of discrete cell populations in embryonic and adult murine thyroid tissues.
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