Conformational changes in 6 MeV electron beam irradiated aqueous bovine serum albumin.

Understanding the folding and unfolding mechanism of the protein is not only crucial in applications like biomedical, pharmaceutical, tissue engineering but also to the food industry. In the present study, an electron beam with 6 MeV energy derived from the Microtron accelerator was utilized to irradiate the aqueous solution of bovine serum albumin (BSA) at fluences of 5 × 10 and 10 × 10 e/cm. The control and irradiated BSA solutions were analyzed using UV-visible and FTIR spectroscopy.

Probing Effect of 6 MeV Electron Beam Irradiation on Haemoglobin Protein Using Spectroscopic Techniques.

In this work, we study the effect of 6 MeV electron beam irradiation on the physicochemical properties of lyophilized Human Haemoglobin A (HbA). Electron beams generated from Race Track Microtron accelerator with energy 6 MeV were used to irradiate HbA at fluences of 5 × 10 e/cm and 10 × 10 e/cm. Pristine and electron beam irradiated HbA were characterized using UV-visible and Fourier transform infrared spectroscopy (FTIR) spectroscopy.

Improved photocatalytic activity of TiO nanoparticles through nitrogen and phosphorus co-doped carbon quantum dots: an experimental and theoretical study.

In this work, we develop a photocatalyst wherein nitrogen and phosphorus co-doped carbon quantum dots are scaffolded onto TiO nanoparticles (NPCQD/TiO), denoted as NPCT hereafter. The developed NPCT photocatalyst exhibits an enhanced visible light photocatalytic hydrogen production of 533 μmol h g compared to nitrogen doped CQD/TiO (478 μmol h g), phosphorus doped CQD/TiO (451 μmol h g) and pure CQD/TiO (427 μmol h g) photocatalysts. The enhanced photocatalytic activity of the NPCT photocatalyst is attributed to the excellent synergy between NPCQDs and TiO nanoparticles, which results in the creation of virtual energy levels, a decrease in work function and suppressed recombination rates, thereby increasing the lifetime of photogenerated electrons.

Investigation of thermoluminescence and photoluminescence properties of Tb, Eu, and Dy doped NaYF phosphors for dosimetric applications.

Hexagonal phase sodium yttrium fluoride activated with lanthanide ions; Tb, Eu and Dy doped NaYF phosphors were synthesized using a simplistic hydrothermal method. The photoluminescence studies demonstrated green, red and blue emission lines corresponding to D → F ( = 6, 5, 4, 3), D → F ( = 1, 2 and 4) and F to H ( = 15/2 and 13/2) transitions, which are characteristic of Tb, Eu and Dy ions, respectively. The as-synthesized samples were subjected to annealing at varying temperatures from 500 °C to 800 °C primarily for the optimization of the thermoluminescence glow curve.

Activity measurement of mixed complex radionuclide like Eu with different methods.

Eu has been standardized by three independent 4π β-γ coincidence counting systems with beta detectors as proportional counter, plastic scintillator and liquid scintillator along with the CIEMAT/NIST method. The average activity concentration by primary methods was linked to key comparison reference value (KCRV) by comparing it with that of 4π γ ionization chamber (GIC) whose calibration factor was determined from the KCRV (BIPM.RI(II)-K1.

Establishment and Dissemination of Radiological Standards in the Field of Diagnostic Radiology in India.

Background: The increased use of ionizing radiation for diagnostic purpose has resulted in an increase in the world population dose. Patient dosimetry in X-ray diagnostic radiology is required to establish diagnostic reference levels (DRLs) and to assess the average dose received by organs and tissues. International bodies have recommended DRLs to be based on dosimetric quantities.

Standardisation of Ba by efficiency extrapolation method and calibration of ionisation chamber.

Ba has been standardised by direct measurements for the first time in the laboratory using two counting systems: (i) the 4πβ (plastic scintillator) -γ coincidence, (ii) the 4πβ (proportional counter) -γ coincidence. Furthermore, this standardisation experiment demonstrates the performance and applicability of the recently developed 4πβ (plastic scintillator)-γ coincidence system for radionuclides decaying with complex decay schemes as well as for e, X-γ emitters. Additionally, Ba solution standards were prepared to calibrate the pressurized 4π γ ionisation chamber and determination of the calibration coefficient.

Development of plastic scintillator based primary standard for activity measurements and its performance evaluation.

4πβ-γ coincidence technique is a powerful tool and widely recognised method to determine the absolute activity concentration of radioactive solutions. A new plastic scintillator based coincidence system has been developed and established as a primary standard for radioactivity measurements. The performance of the system was evaluated by the standardisation of Co radioactive solution due to its simple decay scheme.

Synthesis, Characterization and Anti-Biofilm Efficacy of Polypyrrole-Zinc Oxide Composites.

A nanocomposite of Polypyrrole (PPy) and zinc oxide (ZnO), termed as PPy-ZnO, was synthesized by two step route. In the first step, synthesis of PPy was carried out by chemical oxidative route. In the second step, the PPy-ZnO nanocomposite was synthesized under hydrothermal conditions.

Synthesis, characterization and in vitro study of biocompatible cinnamaldehyde functionalized magnetite nanoparticles (CPGF Nps) for hyperthermia and drug delivery applications in breast cancer.

Cinnamaldehyde, the bioactive component of the spice cinnamon, and its derivatives have been shown to possess anti-cancer activity against various cancer cell lines. However, its hydrophobic nature invites attention for efficient drug delivery systems that would enhance the bioavailability of cinnamaldehyde without affecting its bioactivity. Here, we report the synthesis of stable aqueous suspension of cinnamaldehyde tagged Fe3O4 nanoparticles capped with glycine and pluronic polymer (CPGF NPs) for their potential application in drug delivery and hyperthermia in breast cancer.

Characterization of biocompatible NiCo2O4 nanoparticles for applications in hyperthermia and drug delivery.

Unlabelled: Monodispersed, superparamagnetic nickel cobaltite (NCO) nanoparticles were functionalized using mercaptopropionic acid (MPA). MPA conjugates with NCO forming a metal-carboxylate linkage, with the MPA-MPA interaction occurring via formation of disulfide bonds, leaving another carboxyl end free for additional conjugation. The cytotoxicity studies on NCO-MPA show cell viability of ∼100% up to a dosage of 40 μg/mL on SiHa, MCF7, and B16F10 cell lines, and on mouse primary fibroblasts.